Volume 5 Supplement 1
Proceedings of Fibroproliferative disorders: from biochemical analysis to targeted therapies
Proceedings
Edited by Petro E Petrides and David Brenner
Fibroproliferative disorders: from biochemical analysis to targeted therapies. Go to conference site.
Frauenchiemsee, Germany25-30 September 2010
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Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S1
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Developmental responses to lung injury: repair or fibrosis
Lung development is a complex and finely balanced process. Yet the lung has a relatively limited repertoire of responses to injury, which, depending on severity of the injury and developmental stage and suscep...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S2 -
Aberrant innate immune sensing leads to the rapid progression of idiopathic pulmonary fibrosis
Novel approaches are needed to define subgroups of patients with Idiopathic pulmonary fibrosis (IPF) at risk for acute exacerbations and/or accelerated progression of this generally fatal disease. Progression ...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S3 -
The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis
Under physiological conditions, intracellular and tissue levels of reactive oxygen species (ROS) are carefully controlled and employed as fine modulators of signal transduction, gene expression and cell functi...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S4 -
The myofibroblast, multiple origins for major roles in normal and pathological tissue repair
Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be r...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S5 -
Fibrocytes in health and disease
Fibrocytes, a group of bone marrow-derived mesenchymal progenitor cells, were first described in 1994 as fibroblast-like, peripheral blood cells that migrate to regions of tissue injury. These cells are unique...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S6 -
Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases
Several recent studies have demonstrated that endothelial to mesenchymal transition (EndoMT), a newly recognized type of cellular transdifferentiation may be an important source of myofibroblasts during the de...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S7 -
Connective tissue growth factor in tumor pathogenesis
Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are active in tumor-r...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S8 -
Role of matrix metaloproteases in idiopathic pulmonary fibrosis
Lung fibrosis is the final common pathway of a large variety of chronic lung disorders, named interstitial lung diseases. The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by al...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S9 -
Proteomics approaches to fibrotic disorders
This review provides an introduction to mass spectrometry based proteomics and discusses several proteomics approaches that are relevant in understanding the pathophysiology of fibrotic disorders and the appro...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S10 -
Biomarkers of disease differentiation: HCV recurrence versus acute cellular rejection
The wound-healing process induced by chronic hepatitis C virus (HCV) infection triggers liver damage characterized by fibrosis development and finally cirrhosis. Liver Transplantation (LT) is the optimal surgi...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S11 -
Employment of gene expression profiling to identify transcriptional regulators of hepatic stellate cells
Activated hepatic stellate cells (HSC) play a central role in scar formation that leads to liver fibrosis. The molecular mechanisms underlying this process are not fully understood. Microarray and bioinformati...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S12 -
Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa
Chronic toxicities of locoregional and systemic oncological treatments commonly develop in long-term cancer survivors. Amongst these toxicities, post-radiotherapeutic complications alter patient's quality of l...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S13 -
Fibrosis in the kidney: is a problem shared a problem halved?
Fibrotic disorders are commonplace, take many forms and can be life-threatening. No better example of this exists than the progressive fibrosis that accompanies all chronic renal disease. Renal fibrosis is a d...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S14 -
Progression of renal fibrosis: the underestimated role of endothelial alterations
The vasculature of the kidney is a heterogeneous structure, whose functional integrity is essential for the regulation of renal function. Owing to the importance of the endothelium in vascular biology, chronic...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S15 -
Hypoxia-inducible factor signaling in the development of kidney fibrosis
A discrepancy between oxygen availability and demand has been found in most chronic kidney diseases (CKD) irrespective of etiology. This results from a combination of structural and functional changes that are...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S16 -
Origin of myofibroblasts in liver fibrosis
Most chronic liver diseases of all etiologies result in progressive liver fibrosis. Myofibroblasts produce the extracellular matrix, including type I collagen, which constitutes the fibrous scar in liver fibro...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S17 -
Fibrosis in systemic sclerosis: common and unique pathobiology
Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated with autoimmunity and proliferative/obliterative vasculopathy, shares pathobiologic features in common with other fibrosing illnesse...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S18 -
Molecular targets for therapy in systemic sclerosis
Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Al...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S19 -
Primary myelofibrosis and the "bad seeds in bad soil" concept
Primary Myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by a clonal myeloproliferation and a myelofibrosis. The concomitant presence of neoangiogenesis and osteosclerosis suggests a ...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S20 -
Myelofibrosis: molecular and cell biological aspects
A subset of myeloproliferative disorders (MPN) and myelodyplastic syndromes (MDS) evolves to fibrosis of the bone marrow associated with haematopoietic insufficiency. We have been interested in chemokines invo...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S21 -
Fibrocytes and the pathogenesis of diffuse parenchymal lung disease
Fibrosis is fundamental to the pathogenesis of many chronic lung diseases, including some lung infections, airway diseases such as bronchiectasis and asthma, and most of the diffuse parenchymal lung diseases. ...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S22 -
Mechanisms of pulmonary fibrosis: role of activated myofibroblasts and NADPH oxidase
A common feature of pathological fibrosis involving the lung and other organs is the persistent activation of myofibroblasts in injured tissues. Recent evidence supports the role of a member of the NADPH oxida...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S23 -
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and ext...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S24 -
Replacement of hematopoietic system by allogeneic stem cell transplantation in myelofibrosis patients induces rapid regression of bone marrow fibrosis
Bone marrow fibrosis is a hallmark of primary and post ET/PV myelofibrosis. To investigated the impact of replacement of the hematopoietic system in myelofibrosis patients by allogeneic stem cell transplantati...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S25 -
Reversibility of liver fibrosis
Liver fibrosis, and its end stage cirrhosis are a major cause of morbidity and mortality and therapeutic options are limited. However, the traditional view of liver disease as an irreversible process is obsole...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S26 -
Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo
Sustained inflammation upon chronic liver injury induces the development of liver fibrosis in mice and men. Experimental models of liver fibrosis highlight the importance of hepatic macrophages, so-called Kupf...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S27 -
Reversal of transforming growth factor-β induced epithelial-to-mesenchymal transition and the ZEB proteins
The dynamic process of epithelial-to-mesenchymal transition (EMT) is a causal event in kidney fibrosis. This cellular phenotypic transition involves activation of transcriptional responses and remodeling of ce...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S28 -
Inhibition of collagen fibril formation
The overall aim of presented study is to test the inhibition of the formation of collagen fibrils as the novel approach to reduce accumulation of pathological fibrotic deposits. The main hypothesis is that by ...
Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S29