Levine A, Tenhaken R, Dixon R, Lamb C: H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response. Cell. 1994, 79: 583-593. 10.1016/0092-8674(94)90544-4.
Article
CAS
PubMed
Google Scholar
Jasmer RM, Nahid P, Hopewell PC: Clinical practice. Latent tuberculosis infection. N Engl J Med. 2002, 347: 1860-1866. 10.1056/NEJMcp021045.
Article
PubMed
Google Scholar
Thannickal VJ, Toews GB, White ES, Lynch JP, Martinez FJ: Mechanisms of pulmonary fibrosis. Annu Rev Med. 2004, 55: 395-417. 10.1146/annurev.med.55.091902.103810.
Article
CAS
PubMed
Google Scholar
Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G: Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006, 174: 810-816. 10.1164/rccm.200602-163OC.
Article
PubMed
Google Scholar
Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA, Lansdorp PM, Greider CW, Loyd JE: Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007, 356: 1317-1326. 10.1056/NEJMoa066157.
Article
CAS
PubMed
Google Scholar
Armanios M: Syndromes of telomere shortening. Annu Rev Genomics Hum Genet. 2009, 10: 45-61. 10.1146/annurev-genom-082908-150046.
Article
PubMed Central
CAS
PubMed
Google Scholar
Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, Phillips JA, Lansdorp PM, Loyd JE, Armanios MY: Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA. 2008, 105: 13051-13056. 10.1073/pnas.0804280105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G: The myofibroblast: One function, multiple origins. Am J Pathol. 2007, 170: 1807-1816. 10.2353/ajpath.2007.070112.
Article
PubMed Central
CAS
PubMed
Google Scholar
Desmouliere A, Badid C, Bochaton-Piallat ML, Gabbiani G: Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury. Int J Biochem Cell Biol. 1997, 29: 19-30. 10.1016/S1357-2725(96)00117-3.
Article
CAS
PubMed
Google Scholar
Wipff PJ, Rifkin DB, Meister JJ, Hinz B: Myofibroblast contraction activates latent tgf-beta1 from the extracellular matrix. J Cell Biol. 2007, 179: 1311-1323. 10.1083/jcb.200704042.
Article
PubMed Central
CAS
PubMed
Google Scholar
Desmouliere A, Chaponnier C, Gabbiani G: Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 2005, 13: 7-12. 10.1111/j.1067-1927.2005.130102.x.
Article
PubMed
Google Scholar
Thannickal VJ, Horowitz JC: Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc. 2006, 3: 350-356. 10.1513/pats.200601-001TK.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE: Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem. 2003, 278: 12384-12389. 10.1074/jbc.M208544200.
Article
CAS
PubMed
Google Scholar
Horowitz JC, Lee DY, Waghray M, Keshamouni VG, Thomas PE, Zhang H, Cui Z, Thannickal VJ: Activation of the pro-survival phosphatidylinositol 3-kinase/akt pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 mapk-dependent induction of an autocrine growth factor. J Biol Chem. 2004, 279: 1359-1367.
Article
PubMed Central
CAS
PubMed
Google Scholar
Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ: Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal. 2007, 19: 761-771. 10.1016/j.cellsig.2006.10.001.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vittal R, Horowitz JC, Moore BB, Zhang H, Martinez FJ, Toews GB, Standiford TJ, Thannickal VJ: Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury. Am J Pathol. 2005, 166: 367-375. 10.1016/S0002-9440(10)62260-2.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S, Martinez FJ, Thannickal VJ: NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med. 2009, 15: 1077-1081. 10.1038/nm.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Carnesecchi S, Deffert C, Donati Y, Basset O, Hinz B, Preynat-Seauve O, Guichard C, Arbiser JL, Banfi B, Pache JC, Barazzone-Argiroffo C, Krause KH: A key role for nox4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal. 2011, 15: 607-619. 10.1089/ars.2010.3829.
Article
PubMed Central
CAS
PubMed
Google Scholar
Waghray M, Cui Z, Horowitz JC, Subramanian IM, Martinez FJ, Toews GB, Thannickal VJ: Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J. 2005, 19: 854-856.
CAS
PubMed
Google Scholar
Pache JC, Carnesecchi S, Deffert C, Donati Y, Herrmann FR, Barazzone-Argiroffo C, Krause KH: Nox-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis. Nat Med. 2011, 17: 31-32. 10.1038/nm0111-31.
Article
CAS
PubMed
Google Scholar
Mittal M, Roth M, Konig P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hanze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N: Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit Nox4 in the pulmonary vasculature. Circ Res. 2007, 101: 258-267. 10.1161/CIRCRESAHA.107.148015.
Article
CAS
PubMed
Google Scholar