Leon DA, McCambridge J: Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data. Lancet. 2006, 367 (9504): 52-56. 10.1016/S0140-6736(06)67924-5.
Article
PubMed
Google Scholar
Pares A, Caballeria J, Bruguera M, Torres M, Rodes J: Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage. J Hepatol. 1986, 2 (1): 33-42. 10.1016/S0168-8278(86)80006-X.
Article
CAS
PubMed
Google Scholar
Dienstag JL, Goldin RD, Heathcote EJ, Hann HW, Woessner M, Stephenson SL: Histological outcome during long-term lamivudine therapy. Gastroenterology. 2003, 124 (1): 105-117. 10.1053/gast.2003.50013.
Article
CAS
PubMed
Google Scholar
Poynard T, McHutchison J, Manns M, Trepo C, Lindsay K, Goodman Z: Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology. 2002, 122 (5): 1303-1313. 10.1053/gast.2002.33023.
Article
CAS
PubMed
Google Scholar
Lau DT, Kleiner DE, Park Y, Di Bisceglie AM, Hoofnagle JH: Resolution of chronic delta hepatitis after 12 years of interferon alfa therapy. Gastroenterology. 1999, 117 (5): 1229-1233. 10.1016/S0016-5085(99)70409-9.
Article
CAS
PubMed
Google Scholar
Hammel P, Couvelard A, O'Toole D, Ratouis A, Sauvanet A, Flejou JF: Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 2001, 344 (6): 418-423. 10.1056/NEJM200102083440604.
Article
CAS
PubMed
Google Scholar
Dufour JF, DeLellis R, Kaplan MM: Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med. 1997, 127 (11): 981-985.
Article
CAS
PubMed
Google Scholar
Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S: Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest. 1998, 102 (3): 538-549. 10.1172/JCI1018.
Article
PubMed Central
CAS
PubMed
Google Scholar
Murphy FR, Issa R, Zhou X, Ratnarajah S, Nagase H, Arthur MJ: Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem. 2002, 277 (13): 11069-11076. 10.1074/jbc.M111490200.
Article
CAS
PubMed
Google Scholar
Issa R, Zhou X, Constandinou CM, Fallowfield J, Millward-Sadler H, Gaca MD: Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology. 2004, 126 (7): 1795-1808. 10.1053/j.gastro.2004.03.009.
Article
CAS
PubMed
Google Scholar
Friedman SL, Roll FJ, Boyles J, Bissell DM: Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA. 1985, 82 (24): 8681-8685. 10.1073/pnas.82.24.8681.
Article
PubMed Central
CAS
PubMed
Google Scholar
Friedman SL: Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008, 88 (1): 125-172. 10.1152/physrev.00013.2007.
Article
PubMed Central
CAS
PubMed
Google Scholar
Burt AD, Griffiths MR, Schuppan D, Voss B, MacSween RN: Ultrastructural localization of extracellular matrix proteins in liver biopsies using ultracryomicrotomy and immuno-gold labelling. Histopathology. 1990, 16 (1): 53-58. 10.1111/j.1365-2559.1990.tb01060.x.
Article
CAS
PubMed
Google Scholar
Iredale JP: Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007, 117 (3): 539-548. 10.1172/JCI30542.
Article
PubMed Central
CAS
PubMed
Google Scholar
Elsharkawy AM, Oakley F, Mann DA: The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis. 2005, 10 (5): 927-939. 10.1007/s10495-005-1055-4.
Article
CAS
PubMed
Google Scholar
Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Nakatani T: Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the Transgenic mouse. Hepatology. 2002, 36 (4): 850-860.
Article
CAS
PubMed
Google Scholar
Issa R, Zhou X, Trim N, Millward-Sadler H, Krane S, Benyon C: Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J. 2003, 17 (1): 47-49.
CAS
PubMed
Google Scholar
Zhou X, Murphy FR, Gehdu N, Zhang J, Iredale JP, Benyon RC: Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. J Biol Chem. 2004, 279 (23): 23996-24006. 10.1074/jbc.M311668200.
Article
CAS
PubMed
Google Scholar
Trim N, Issa R, Krane S, Benyon RC, Iredale JP: Intact collagen-1 inhibits hepatic stellate cell activation and promotes persistence of activated HSC in vivo. Hepatology. 2000, 183A-32
Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC: DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest. 2001, 108 (9): 1369-1378.
Article
PubMed Central
CAS
PubMed
Google Scholar
Georges PC, Hui JJ, Gombos Z, McCormick ME, Wang AY, Uemura M: Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007, 293 (6): G1147-G1154. 10.1152/ajpgi.00032.2007.
Article
CAS
PubMed
Google Scholar
Li Z, Dranoff JA, Chan EP, Uemura M, Sevigny J, Wells RG: Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology. 2007, 46 (4): 1246-1256. 10.1002/hep.21792.
Article
CAS
PubMed
Google Scholar
Wells RG: The role of matrix stiffness in regulating cell behavior. Hepatology. 2008, 47 (4): 1394-1400. 10.1002/hep.22193.
Article
CAS
PubMed
Google Scholar
Wells RG: The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis. J Clin Gastroenterol. 2005, 39 (4 Suppl 2): S158-S161.
Article
CAS
PubMed
Google Scholar
Sagir A, Erhardt A, Schmitt M, Haussinger D: Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology. 2008, 47 (2): 592-595.
Article
CAS
PubMed
Google Scholar
Arena U, Vizzutti F, Corti G, Ambu S, Stasi C, Bresci S: Acute viral hepatitis increases liver stiffness values measured by transient elastography. Hepatology. 2008, 47 (2): 380-384.
Article
CAS
PubMed
Google Scholar
Henderson NC, Iredale JP: Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci (Lond). 2007, 112 (5): 265-280. 10.1042/CS20060242.
Article
CAS
Google Scholar
Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H: Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology. 2005, 128 (1): 138-146. 10.1053/j.gastro.2004.10.005.
Article
CAS
PubMed
Google Scholar
Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S: Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005, 115 (1): 56-65.
Article
PubMed Central
CAS
PubMed
Google Scholar
Matsuoka M, Tsukamoto H: Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 1990, 11 (4): 599-605. 10.1002/hep.1840110412.
Article
CAS
PubMed
Google Scholar
Friedman SL: Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis. J Clin Invest. 2005, 115 (1): 29-32.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fischer R, Cariers A, Reinehr R, Haussinger D: Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells. Gastroenterology. 2002, 123 (3): 845-861. 10.1053/gast.2002.35384.
Article
CAS
PubMed
Google Scholar
Knittel T, Mehde M, Kobold D, Saile B, Dinter C, Ramadori G: Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol. 1999, 30 (1): 48-60. 10.1016/S0168-8278(99)80007-5.
Article
CAS
PubMed
Google Scholar
Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, Duffield JS: Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol. 2007, 178 (8): 5288-5295.
Article
CAS
PubMed
Google Scholar
Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, Duffield JS: Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol. 2007, 178 (8): 5288-5295.
Article
CAS
PubMed
Google Scholar
Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B: Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology. 2006, 130 (2): 435-452. 10.1053/j.gastro.2005.10.055.
Article
CAS
PubMed
Google Scholar
Pellicoro A, Aucott RL, Ramachandran P, Robson RJ, Fallowfield JA, Snowdon VS, Hartland SN, Vernon M, Duffield JS, Benyon RC, Forbes SJ, Iredale JP: Elastin Accumulation Is Regulated at the Level of Degradation by Macrophage Metalloelastase (MMP-12) during Experimental Liver Fibrosis. Hepatology. 2011, hep.25567.
Google Scholar