Eckardt KU, Bernhardt WM, Weidemann A, Warnecke C, Rosenberger C, Wiesener MS, Willam C: Role of hypoxia in the pathogenesis of renal disease. Kidney Int Suppl. 2005, Dec (99): S46-S51.
Article
Google Scholar
Heyman SN, Khamaisi M, Rosen S, Rosenberger C: Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol. 2008, 28: 998-1006. 10.1159/000146075.
Article
CAS
PubMed
Google Scholar
Haase VH: Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol. 2006, 291: F271-281. 10.1152/ajprenal.00071.2006.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nangaku M, Inagi R, Miyata T, Fujita T: Hypoxia and hypoxia-inducible factor in renal disease. Nephron Exp Nephrol. 2008, 110: e1-7. 10.1159/000148256.
Article
PubMed
Google Scholar
Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, et al: Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest. 2007, 117: 3810-3820.
PubMed Central
CAS
PubMed
Google Scholar
Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Grone HJ, Schlondorff D, Cohen CD: Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol. 2010, 176: 594-607. 10.2353/ajpath.2010.090268.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kewley RJ, Whitelaw ML, Chapman-Smith A: The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol. 2004, 36: 189-204. 10.1016/S1357-2725(03)00211-5.
Article
CAS
PubMed
Google Scholar
Semenza GL: Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999, 15: 551-578. 10.1146/annurev.cellbio.15.1.551.
Article
CAS
PubMed
Google Scholar
Wenger RH, Stiehl DP, Camenisch G: Integration of oxygen signaling at the consensus HRE. Sci STKE. 2005, 2005: re12-10.1126/stke.3062005re12.
PubMed
Google Scholar
Semenza GL: HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol. 2001, 13: 167-171. 10.1016/S0955-0674(00)00194-0.
Article
CAS
PubMed
Google Scholar
Haase VH: Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int. 2009, 76: 492-499. 10.1038/ki.2009.222.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haase VH: Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol. 2010, 299: F1-13. 10.1152/ajprenal.00174.2010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis [see comments]. Nature. 1999, 399: 271-275. 10.1038/20459.
Article
CAS
PubMed
Google Scholar
Kaelin WG, Ratcliffe PJ: Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008, 30: 393-402. 10.1016/j.molcel.2008.04.009.
Article
CAS
PubMed
Google Scholar
Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, et al: Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol. 2008, 295: F1023-1029. 10.1152/ajprenal.90209.2008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH: Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol. 2004, 287: F1223-1232. 10.1152/ajprenal.00245.2004.
Article
CAS
PubMed
Google Scholar
Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR: DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int. 2003, 64: 2079-2091. 10.1046/j.1523-1755.2003.00306.x.
Article
CAS
PubMed
Google Scholar
Kietzmann T, Roth U, Jungermann K: Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood. 1999, 94: 4177-4185.
CAS
PubMed
Google Scholar
Matsuo S, Lopez-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA: Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice. Kidney Int. 2005, 67: 2221-2238. 10.1111/j.1523-1755.2005.00327.x.
Article
CAS
PubMed
Google Scholar
Oda T, Jung YO, Kim HS, Cai X, Lopez-Guisa JM, Ikeda Y, Eddy AA: PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int. 2001, 60: 587-596. 10.1046/j.1523-1755.2001.030002587.x.
Article
CAS
PubMed
Google Scholar
Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest. 2002, 110: 341-350.
Article
PubMed Central
CAS
PubMed
Google Scholar
Iwano M, Neilson EG: Mechanisms of tubulointerstitial fibrosis. Curr Opin Nephrol Hypertens. 2004, 13: 279-284. 10.1097/00041552-200405000-00003.
Article
PubMed
Google Scholar
Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003, 112: 1776-1784.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu Y: Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol. 2004, 15: 1-12. 10.1097/01.ASN.0000106015.29070.E7.
Article
CAS
PubMed
Google Scholar
Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006, 440: 1222-1226. 10.1038/nature04695.
Article
CAS
PubMed
Google Scholar
Lucero HA, Kagan HM: Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci. 2006, 63: 2304-2316. 10.1007/s00018-006-6149-9.
Article
CAS
PubMed
Google Scholar
Kagan HM, Li W: Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003, 88: 660-672. 10.1002/jcb.10413.
Article
CAS
PubMed
Google Scholar
Traykova-Brauch M, Schonig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, et al: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med. 2008, 14: 979-984. 10.1038/nm.1865.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen X, Wang J, Zhou F, Wang X, Feng Z: STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells. Kidney Int. 2003, 64: 459-467. 10.1046/j.1523-1755.2003.00133.x.
Article
CAS
PubMed
Google Scholar
Yu L, Border WA, Huang Y, Noble NA: TGF-beta isoforms in renal fibrogenesis. Kidney Int. 2003, 64: 844-856. 10.1046/j.1523-1755.2003.00162.x.
Article
CAS
PubMed
Google Scholar
Fine LG, Norman JT: Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int. 2008, 74: 867-872. 10.1038/ki.2008.350.
Article
CAS
PubMed
Google Scholar
Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Grone HJ, Schlondorff D, Cohen CD: Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol. 176: 594-607.
Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, et al: Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol. 2007, 18: 1218-1226. 10.1681/ASN.2006060639.
Article
CAS
PubMed
Google Scholar
Hill P, Shukla D, Tran MG, Aragones J, Cook HT, Carmeliet P, Maxwell PH: Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol. 2008, 19: 39-46. 10.1681/ASN.2006090998.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haase VH: The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int. 2006, 69: 1302-1307.
CAS
PubMed
Google Scholar
Orphanides C, Fine LG, Norman JT: Hypoxia stimulates proximal tubular cell matrix production via a TGF- beta1-independent mechanism. Kidney Int. 1997, 52: 637-647. 10.1038/ki.1997.377.
Article
CAS
PubMed
Google Scholar
Sanchez-Elsner T, Botella LM, Velasco B, Corbi A, Attisano L, Bernabeu C: Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001, 276: 38527-38535. 10.1074/jbc.M104536200.
Article
CAS
PubMed
Google Scholar
Sanchez-Elsner T, Botella LM, Velasco B, Langa C, Bernabeu C: Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. Journal of Biological Chemistry. 2002, 277: 43799-43808. 10.1074/jbc.M207160200.
Article
CAS
PubMed
Google Scholar
Sanchez-Elsner T, Ramirez JR, Sanz-Rodriguez F, Varela E, Bernabeu C, Botella LM: A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol. 2004, 336: 9-24. 10.1016/j.jmb.2003.12.023.
Article
CAS
PubMed
Google Scholar
Falanga V, Zhou L, Yufit T: Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1. J Cell Physiol. 2002, 191: 42-50. 10.1002/jcp.10065.
Article
CAS
PubMed
Google Scholar
Saed GM, Zhang W, Chegini N, Holmdahl L, Diamond MP: Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor-beta1. Wound Repair Regen. 1999, 7: 504-510. 10.1046/j.1524-475X.1999.00504.x.
Article
CAS
PubMed
Google Scholar
Page EL, Chan DA, Giaccia AJ, Levine M, Richard DE: Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell. 2008, 19: 86-94. 10.1091/mbc.E07-06-0612.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sachse A, Wolf G: Angiotensin II-induced reactive oxygen species and the kidney. J Am Soc Nephrol. 2007, 18: 2439-2446. 10.1681/ASN.2007020149.
Article
CAS
PubMed
Google Scholar
Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE: Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species. Mol Biol Cell. 2010, 21 (18): 3247-3257. 10.1091/mbc.E10-01-0025. Epub 2010 Jul 21
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang Z, Tang L, Zhu Q, Yi F, Zhang F, Li PL, Li N: Hypoxia-inducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 2011, 79 (3): 300-310. 10.1038/ki.2010.326. Epub 2010 Sep 29
Article
PubMed Central
CAS
PubMed
Google Scholar
Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U: Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA. 2008, 105: 6392-6397. 10.1073/pnas.0802047105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kaidi A, Williams AC, Paraskeva C: Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol. 2007, 9: 210-217. 10.1038/ncb1534.
Article
CAS
PubMed
Google Scholar
Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, et al: VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol. 2007, 27: 157-169. 10.1128/MCB.00892-06.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeisberg M, Duffield JS: Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol. 2010, 21: 1247-1253. 10.1681/ASN.2010060616.
Article
PubMed
Google Scholar
Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008, 173: 1617-1627. 10.2353/ajpath.2008.080433.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R: Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol. 2008, 19: 2282-2287. 10.1681/ASN.2008050513.
Article
PubMed Central
PubMed
Google Scholar
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, Csiszar K, Fong KS, Vega S, Nieto MA, Cano A, Portillo F: A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. Embo J. 2005, 24: 3446-3458. 10.1038/sj.emboj.7600781.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hohenstein B, Hausknecht B, Boehmer K, Riess R, Brekken RA, Hugo CP: Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney Int. 2006, 69: 1654-1661. 10.1038/sj.ki.5000294.
Article
CAS
PubMed
Google Scholar