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Research
Dupuytren’s disease is a fibroproliferative disease of the hand and fingers, which usually manifests as two different phenotypes within the same patient. The disease first causes a nodule in the palm of the ha...
Fibrogenesis & Tissue Repair 2016 9:9
Published on: 29 June 2016
Research
Hepatic fibrosis is a prominent pathological feature associated with chronic liver disease including non-alcoholic hepatosteatosis (NASH), and a precursor for liver cancer development. We previously reported t...
Fibrogenesis & Tissue Repair 2016 9:8
Published on: 14 June 2016
Research
Excessive accumulation of extracellular matrix (ECM) proteins is the hallmark of fibrotic diseases, including skin fibrosis. This response relies on the activation of dermal fibroblasts that evolve into a pro-...
Fibrogenesis & Tissue Repair 2016 9:7
Published on: 10 May 2016
Research
Mice lacking glycosylated lysosomal membrane protein (Glmp gt/gt mice) have liver fibrosis as the predominant phenotype due to chronic liver inju...
Fibrogenesis & Tissue Repair 2016 9:5
Published on: 28 April 2016
Research
Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows the tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can ...
Fibrogenesis & Tissue Repair 2016 9:6
Published on: 27 April 2016
Research
Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation an...
Fibrogenesis & Tissue Repair 2016 9:4
Published on: 31 March 2016
Review
Tissue engineering is a rapidly advancing field that is likely to transform how medicine is practised in the near future. For hollow organs such as those found in the cardiovascular and respiratory systems or ...
Fibrogenesis & Tissue Repair 2016 9:3
Published on: 23 March 2016
Research
Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of TLR4 signaling on the gene expression net...
Fibrogenesis & Tissue Repair 2016 9:2
Published on: 18 February 2016
Review
Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Recent eviden...
Fibrogenesis & Tissue Repair 2016 9:1
Published on: 13 February 2016
Research
Persistent pulmonary hypertension of the newborn (PPHN) is characterized by vasoconstriction and pulmonary vascular remodeling. Remodeling is believed to be a response to physical or chemical stimuli including...
Fibrogenesis & Tissue Repair 2015 8:20
Published on: 1 November 2015
Research
Macrophages play critical roles in liver regeneration, fibrosis development and resolution. They are among the first responders to liver injury and are implicated in orchestrating the fibrogenic response via m...
Fibrogenesis & Tissue Repair 2015 8:19
Published on: 15 October 2015
Review
Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular matrix proteins such as collagens and fibronectin, f...
Fibrogenesis & Tissue Repair 2015 8:18
Published on: 1 October 2015
Research
Hepatic fibrosis, which is the excessive accumulation of extracellular matrices (ECMs) produced mainly from activated hepatic stellate cells (HSCs), develops to cirrhosis over several decades. There are no val...
Fibrogenesis & Tissue Repair 2015 8:17
Published on: 15 September 2015
Review
Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field—but what is the quickest road to get there? In li...
Fibrogenesis & Tissue Repair 2015 8:16
Published on: 1 September 2015
Research
Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised ...
Fibrogenesis & Tissue Repair 2015 8:15
Published on: 21 August 2015
Research
Liver fibrosis is characterized by the excessive formation and accumulation of matrix proteins as a result of wound healing in the liver. A main event during fibrogenesis is the activation of the liver residen...
Fibrogenesis & Tissue Repair 2015 8:14
Published on: 6 August 2015
Research
Chronic kidney disease (CKD) is an independent risk factor for the development and severity of coronary artery disease (CHD) and endothelial dysfunction. There is an increase in the circulating angiogenesis in...
Fibrogenesis & Tissue Repair 2015 8:13
Published on: 21 July 2015
Research
The process of epithelial-mesenchymal transition (EMT), which is generally defined by phenotypic changes of injured tubules such as loss of epithelial markers or acquisition of mesenchymal markers, implies var...
Fibrogenesis & Tissue Repair 2015 8:12
Published on: 10 July 2015
Research
A major health disparity suffered by African Americans (AA) is a predisposition toward fibrotic diseases of the skin, lung, and other organs. We previously showed that healthy AA and scleroderma (systemic scle...
Fibrogenesis & Tissue Repair 2015 8:11
Published on: 20 June 2015
Research
Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties. The simultaneous use of PTX and antifungal therapy (itraconazole) has previously been evaluated in an experi...
Fibrogenesis & Tissue Repair 2015 8:10
Published on: 1 June 2015
Review
Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the symptoms of many human diseases have been reversed in animal models with iPSC therapy, setting the stage for future clinical developmen...
Fibrogenesis & Tissue Repair 2015 8:9
Published on: 15 May 2015
Research
Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the dis...
Fibrogenesis & Tissue Repair 2015 8:8
Published on: 5 May 2015
Review
Over the last decade, it has become clear that the role of angiotensin II extends far beyond recognized renal and cardiovascular effects. The presence of an autologous renin-angiotensin system has been demonst...
Fibrogenesis & Tissue Repair 2015 8:7
Published on: 23 April 2015
Research
While kidney injury is associated with re-expression of numerous Wnt ligands and receptors, molecular mechanisms which underlie regulation of distinct Wnt signaling pathways and ensuing biological consequences...
Fibrogenesis & Tissue Repair 2015 8:6
Published on: 16 April 2015
Research
Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K+ channel KCa3.1 reduces constitutive α-SMA and Smad2/3 nuclear tran...
Fibrogenesis & Tissue Repair 2015 8:5
Published on: 26 March 2015
