Laurent GJ, Harrison NK, McAnulty RJ: The regulation of collagen production in normal lung and during interstitial lung disease. Postgrad Med J. 1988, 64 (Suppl 4): 26-34.
PubMed
Google Scholar
Royce SG, Cheng V, Samuel CS, Tang ML: The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol. 2012, 351 (2): 167-175.
CAS
PubMed
Google Scholar
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005, 11 (11): 1173-1179.
CAS
PubMed
Google Scholar
Reilkoff RA, Bucala R, Herzog EL: Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol. 2011, 11 (6): 427-435.
PubMed Central
CAS
PubMed
Google Scholar
Quan TE, Cowper SE, Bucala R: The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep. 2006, 8 (2): 145-150.
CAS
PubMed
Google Scholar
Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA: Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009, 119 (1): 213-224.
PubMed Central
CAS
PubMed
Google Scholar
Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T, Shimokata K, Hasegawa Y: Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009, 43 (2): 161-172.
PubMed Central
PubMed
Google Scholar
Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, Noble PW, Hogan BL: Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011, 108 (52): E1475-E1483.
PubMed Central
CAS
PubMed
Google Scholar
Ohta K, Mortenson RL, Clark RA, Hirose N, King TE: Immunohistochemical identification and characterization of smooth muscle-like cells in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1995, 152 (5 Pt 1): 1659-1665.
CAS
PubMed
Google Scholar
Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA: Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol. 2003, 162 (2): 533-546.
PubMed Central
CAS
PubMed
Google Scholar
Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993, 122 (1): 103-111.
CAS
PubMed
Google Scholar
Jakubzick C, Choi ES, Kunkel SL, Evanoff H, Martinez FJ, Puri RK, Flaherty KR, Toews GB, Colby TV, Kazerooni EA, Gross BH, Travis WD, Hogaboam CM: Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia. J Clin Pathol. 2004, 57 (5): 477-486.
PubMed Central
CAS
PubMed
Google Scholar
Murray LA, Argentieri RL, Farrell FX, Bracht M, Sheng H, Whitaker B, Beck H, Tsui P, Cochlin K, Evanoff HL, Hogaboam CM, Das AM: Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2. Int J Biochem Cell Biol. 2008, 40 (10): 2174-2182.
CAS
PubMed
Google Scholar
Hancock A, Armstrong L, Gama R, Millar A: Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol. 1998, 18 (1): 60-65.
CAS
PubMed
Google Scholar
Murray LA, Chen Q, Kramer MS, Hesson DP, Argentieri RL, Peng X, Gulati M, Homer RJ, Russell T, van Rooijen N, Elias JA, Hogaboam CM, Herzog EL: TGF-beta driven lung fibrosis is macrophage dependent and blocked by serum amyloid P. Int J Biochem Cell Biol. 2011, 43 (1): 154-162.
CAS
PubMed
Google Scholar
Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL: Semaphorin 7a + regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-beta1-induced pulmonary fibrosis. Am J Respir Crit Care Med. 2013, 187 (2): 180-188.
PubMed Central
CAS
PubMed
Google Scholar
Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A: IL-13 signaling through the IL-13alpha(2) receptor is involved in induction of TGF-beta(1) production and fibrosis. Nat Med. 2005, 12 (1): 99-106.
PubMed
Google Scholar
Moodley YP, Scaffidi AK, Misso NL, Keerthisingam C, McAnulty RJ, Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA: Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation. Am J Pathol. 2003, 163 (1): 345-354.
PubMed Central
CAS
PubMed
Google Scholar
Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA: Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. Br J Pharmacol. 2002, 136 (5): 793-801.
PubMed Central
CAS
PubMed
Google Scholar
Keerthisingam CB, Jenkins RG, Harrison NK, Hernandez-Rodriguez NA, Booth H, Laurent GJ, Hart SL, Foster ML, McAnulty RJ: Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am J Pathol. 2001, 158 (4): 1411-1422.
PubMed Central
CAS
PubMed
Google Scholar
Jacoby DB, Gleich GJ, Fryer AD: Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J Clin Invest. 1993, 91 (4): 1314-1318.
PubMed Central
CAS
PubMed
Google Scholar
Tanaka T, Yoshimi M, Maeyama T, Hagimoto N, Kuwano K, Hara N: Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur Respir J. 2002, 20 (2): 359-368.
CAS
PubMed
Google Scholar
Ramos C, Montano M, Garcia-Alvarez J, Ruiz V, Uhal BD, Selman M, Pardo A: Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. Am J Respir Cell Mol Biol. 2001, 24 (5): 591-598.
CAS
PubMed
Google Scholar
Mutsaers SE, Bishop JE, McGrouther G, Laurent GJ: Mechanisms of tissue repair: from wound healing to fibrosis. Int J Biochem Cell Biol. 1997, 29 (1): 5-17.
CAS
PubMed
Google Scholar
Wynn TA: Integrating mechanisms of pulmonary fibrosis. J Exp Med. 2011, 208 (7): 1339-1350.
PubMed Central
CAS
PubMed
Google Scholar
Demedts IK, Brusselle GG, Bracke KR, Vermaelen KY, Pauwels RA: Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol. 2005, 5 (3): 257-263.
CAS
PubMed
Google Scholar
Fukuda Y, Ishizaki M, Kudoh S, Kitaichi M, Yamanaka N: Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. Lab Invest. 1998, 78 (6): 687-698.
CAS
PubMed
Google Scholar
Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP: Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011, 179 (4): 1733-1745.
PubMed Central
CAS
PubMed
Google Scholar
Chen QK, Lee K, Radisky DC, Nelson CM: Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation. 2013, 86 (3): 126-32.
PubMed Central
CAS
PubMed
Google Scholar
Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA: Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002, 110 (4): 463-474.
PubMed Central
CAS
PubMed
Google Scholar
Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR: IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells. J Allergy Clin Immunol. 2010, 126 (2): 366-374. 374.e1-8
CAS
PubMed
Google Scholar
Fujishima S, Shiomi T, Yamashita S, Yogo Y, Nakano Y, Inoue T, Nakamura M, Tasaka S, Hasegawa N, Aikawa N, Ishizaka A, Okada Y: Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis. Arch Pathol Lab Med. 2010, 134 (8): 1136-1142.
CAS
PubMed
Google Scholar
Rowe RG, Keena D, Sabeh F, Willis AL, Weiss SJ: Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers. Am J Physiol. 2011, 301 (5): L683-L692.
CAS
Google Scholar
Checa M, Ruiz V, Montano M, Velazquez-Cruz R, Selman M, Pardo A: MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis. Hum Genet. 2008, 124 (5): 465-472.
CAS
PubMed
Google Scholar
Rogliani P, Mura M, Mattia P, Ferlosio A, Farinelli G, Mariotta S, Graziano P, Pezzuto G, Ricci A, Saltini C, Orlandi A: HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema. Respir Med. 2008, 102 (12): 1753-1761.
PubMed
Google Scholar
Wygrecka M, Kwapiszewska G, Jablonska E, von Gerlach S, Henneke I, Zakrzewicz D, Guenther A, Preissner KT, Markart P: Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011, 183 (12): 1703-1714.
CAS
PubMed
Google Scholar
Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ: Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol. 2000, 278 (1): L193-L201.
CAS
PubMed
Google Scholar
Wygrecka M, Dahal BK, Kosanovic D, Petersen F, Taborski B, von Gerlach S, Didiasova M, Zakrzewicz D, Preissner KT, Schermuly RT, Markart P: Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-alpha/Raf-1/p44/42 signaling pathway. Am J Pathol. 2013, 182 (6): 2094-2108.
CAS
PubMed
Google Scholar
Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC: Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol. 2005, 166 (5): 1353-1365.
PubMed Central
CAS
PubMed
Google Scholar
Burch ML, Ballinger ML, Yang SN, Getachew R, Itman C, Loveland K, Osman N, Little PJ: Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor. J Biol Chem. 2010, 285 (35): 26798-26805.
PubMed Central
CAS
PubMed
Google Scholar
Zhu W, Bi M, Liu Y, Wang Y, Pan F, Qiu L, Guo A, Lv H, Yao P, Zhang N, Wang P: Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-beta1 in ovalbumin-allergic rats. Inhal Toxicol. 2013, 25 (10): 577-586.
CAS
PubMed
Google Scholar
Lorand L, Graham RM: Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev. 2003, 4 (2): 140-156.
CAS
Google Scholar
Iismaa SE, Mearns BM, Lorand L, Graham RM: Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders. Physiol Rev. 2009, 89 (3): 991-1023.
CAS
PubMed
Google Scholar
Verderio EA, Johnson T, Griffin M: Tissue transglutaminase in normal and abnormal wound healing: review article. Amino acids. 2004, 26 (4): 387-404.
CAS
PubMed
Google Scholar
Mhaouty-Kodja S: Ghalpha/tissue transglutaminase 2: an emerging G protein in signal transduction. Biol Cell. 2004, 96 (5): 363-367.
CAS
PubMed
Google Scholar
Akimov SS, Krylov D, Fleischman LF, Belkin AM: Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol. 2000, 148 (4): 825-838.
PubMed Central
CAS
PubMed
Google Scholar
Mehta K, Fok JY, Mangala LS: Tissue transglutaminase: from biological glue to cell survival cues. Front Biosci. 2006, 11: 173-185.
PubMed
Google Scholar
Stephens P, Grenard P, Aeschlimann P, Langley M, Blain E, Errington R, Kipling D, Thomas D, Aeschlimann D: Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. J Cell Sci. 2004, 117 (Pt 15): 3389-3403.
CAS
PubMed
Google Scholar
Akimov SS, Belkin AM: Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood. 2001, 98 (5): 1567-1576.
CAS
PubMed
Google Scholar
Grenard P, Bresson-Hadni S, El Alaoui S, Chevallier M, Vuitton DA, Ricard-Blum S: Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis. J Hepatol. 2001, 35 (3): 367-375.
CAS
PubMed
Google Scholar
Qiu JF, Zhang ZQ, Chen W, Wu ZY: Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase. World J Gastroenterol. 2007, 13 (32): 4328-4332.
PubMed Central
CAS
PubMed
Google Scholar
Johnson TS, Griffin M, Thomas GL, Skill J, Cox A, Yang B, Nicholas B, Birckbichler PJ, Muchaneta-Kubara C, Meguid El Nahas A: The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis. J Clin Investig. 1997, 99 (12): 2950-2960.
PubMed Central
CAS
PubMed
Google Scholar
Shweke N, Boulos N, Jouanneau C, Vandermeersch S, Melino G, Dussaule JC, Chatziantoniou C, Ronco P, Boffa JJ: Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol. 2008, 173 (3): 631-642.
PubMed Central
CAS
PubMed
Google Scholar
Huang L, Haylor JL, Hau Z, Jones RA, Vickers ME, Wagner B, Griffin M, Saint RE, Coutts IG, El Nahas AM, Johnson TS: Transglutaminase inhibition ameliorates experimental diabetic nephropathy. Kidney Int. 2009, 76 (4): 383-394.
CAS
PubMed
Google Scholar
Griffin M, Smith LL, Wynne J: Changes in transglutaminase activity in an experimental model of pulmonary fibrosis induced by paraquat. Br J Exp Pathol. 1979, 60 (6): 653-661.
PubMed Central
CAS
PubMed
Google Scholar
Oh K, Park HB, Byoun OJ, Shin DM, Jeong EM, Kim YW, Kim YS, Melino G, Kim IG, Lee DS: Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. J Exp Med. 2011, 208 (8): 1707-1719.
PubMed Central
CAS
PubMed
Google Scholar
Olsen KC, Sapinoro RE, Kottmann RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ: Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med. 2011, 184 (6): 699-707.
PubMed Central
CAS
PubMed
Google Scholar
Rucker RB, Murray J: Cross-linking amino acids in collagen and elastin. Am J Clin Nutr. 1978, 31 (7): 1221-1236.
CAS
PubMed
Google Scholar
Yamauchi M, Shiiba M: Lysine hydroxylation and cross-linking of collagen. Meth Mol Biol (Clifton, N J). 2008, 446: 95-108.
CAS
Google Scholar
Gonzalez GE, Rhaleb NE, Nakagawa P, Liao TD, Liu Y, Leung P, Dai X, Yang XP, Carretero OA: N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. Clin Sci (Lond). 2014, 126 (1): 85-94.
CAS
Google Scholar
Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L: Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins. J Pathol. 2013, 229 (5): 685-696.
CAS
PubMed
Google Scholar
Ohmura H, Yasukawa H, Minami T, Sugi Y, Oba T, Nagata T, Kyogoku S, Ohshima H, Aoki H, Imaizumi T: Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice. Hypertens Res. 2012, 35 (11): 1063-1068.
CAS
PubMed
Google Scholar
Akiri G, Sabo E, Dafni H, Vadasz Z, Kartvelishvily Y, Gan N, Kessler O, Cohen T, Resnick M, Neeman M, Neufeld G: Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo. Cancer Res. 2003, 63 (7): 1657-1666.
CAS
PubMed
Google Scholar
Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M, Mikels A, Vaysberg M, Ghermazien H, Wai C, Garcia CA, Velayo AC, Jorgensen B, Biermann D, Tsai D, Green J, Zaffryar-Eilot S, Holzer A, Ogg S, Thai D, Neufeld G, Van Vlasselaer P, Smith V: Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med. 2010, 16 (9): 1009-1017.
CAS
PubMed
Google Scholar
Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, Izhak OB, Neufeld G: Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol. 2005, 43 (3): 499-507.
CAS
PubMed
Google Scholar
Marinkovic A, Liu F, Tschumperlin DJ: Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts. Am J Respir Cell Mol Biol. 2013, 48 (4): 422-430.
PubMed Central
CAS
PubMed
Google Scholar
Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, Tschumperlin DJ: Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010, 190 (4): 693-706.
PubMed Central
CAS
PubMed
Google Scholar
Wipff PJ, Rifkin DB, Meister JJ, Hinz B: Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol. 2007, 179 (6): 1311-1323.
PubMed Central
CAS
PubMed
Google Scholar
Marinkovic A, Mih JD, Park JA, Liu F, Tschumperlin DJ: Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-beta responsiveness. Am J Physiol Lung Cell Mol Physiol. 2012, 303 (3): L169-L180.
PubMed Central
CAS
PubMed
Google Scholar
Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM: Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005, 8 (3): 241-254.
CAS
PubMed
Google Scholar
Adair-Kirk TL, Senior RM: Fragments of extracellular matrix as mediators of inflammation. Int J Biochem Cell Biol. 2008, 40 (6–7): 1101-1110.
PubMed Central
CAS
PubMed
Google Scholar
Kuntz RM, Saltzman WM: Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration. Biophys J. 1997, 72 (3): 1472-1480.
PubMed Central
CAS
PubMed
Google Scholar
Bohnsack JF, Akiyama SK, Damsky CH, Knape WA, Zimmerman GA: Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin. J Exp Med. 1990, 171 (4): 1221-1237.
CAS
PubMed
Google Scholar
Walzog B, Schuppan D, Heimpel C, Hafezi-Moghadam A, Gaehtgens P, Ley K: The leukocyte integrin Mac-1 (CD11b/CD18) contributes to binding of human granulocytes to collagen. Exp Cell Res. 1995, 218 (1): 28-38.
CAS
PubMed
Google Scholar
Roberts AB, Anzano MA, Lamb LC, Smith JM, Sporn MB: New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci U S A. 1981, 78 (9): 5339-5343.
PubMed Central
CAS
PubMed
Google Scholar
Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986, 83 (12): 4167-4171.
PubMed Central
CAS
PubMed
Google Scholar
Annes JP, Munger JS, Rifkin DB: Making sense of latent TGFbeta activation. J Cell Sci. 2003, 116 (Pt 2): 217-224.
CAS
PubMed
Google Scholar
Dallas SL, Park-Snyder S, Miyazono K, Twardzik D, Mundy GR, Bonewald LF: Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. J Biol Chem. 1994, 269 (9): 6815-6821.
CAS
PubMed
Google Scholar
Miyazono K, Olofsson A, Colosetti P, Heldin CH: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J. 1991, 10 (5): 1091-1101.
PubMed Central
CAS
PubMed
Google Scholar
Jenkins G: The role of proteases in transforming growth factor-beta activation. Int J Biochem Cell Biol. 2008, 40 (6–7): 1068-1078.
CAS
PubMed
Google Scholar
Horiguchi M, Ota M, Rifkin DB: Matrix control of transforming growth factor-beta function. J Biochem. 2012, 152 (4): 321-329.
PubMed Central
CAS
PubMed
Google Scholar
Chaurasia P, Aguirre-Ghiso JA, Liang OD, Gardsvoll H, Ploug M, Ossowski L: A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth. J Biol Chem. 2006, 281 (21): 14852-14863.
CAS
PubMed
Google Scholar
Lyons RM, Gentry LE, Purchio AF, Moses HL: Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol. 1990, 110 (4): 1361-1367.
CAS
PubMed
Google Scholar
Odekon LE, Blasi F, Rifkin DB: Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta. J Cell Physiol. 1994, 158 (3): 398-407.
CAS
PubMed
Google Scholar
Munger JS, Harpel JG, Giancotti FG, Rifkin DB: Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell. 1998, 9 (9): 2627-2638.
PubMed Central
CAS
PubMed
Google Scholar
Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J: Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J Immunol. 2004, 173 (3): 2099-2108.
CAS
PubMed
Google Scholar
Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura SL: Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol. 2006, 169 (2): 405-415.
PubMed Central
CAS
PubMed
Google Scholar
Wipff PJ, Hinz B: Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. Eur J Cell Biol. 2008, 87 (8–9): 601-615.
CAS
PubMed
Google Scholar
Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL: The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002, 157 (3): 493-507.
PubMed Central
CAS
PubMed
Google Scholar
Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL: Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alphavbeta8-mediated activation of TGF-beta. J Clin Investig. 2011, 121 (7): 2863-2875.
PubMed Central
CAS
PubMed
Google Scholar
Sheppard D: Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 2005, 24 (3): 395-402.
CAS
PubMed
Google Scholar
Buscemi L, Ramonet D, Klingberg F, Formey A, Smith-Clerc J, Meister JJ, Hinz B: The single-molecule mechanics of the latent TGF-beta1 complex. Curr Biol. 2011, 21 (24): 2046-2054.
CAS
PubMed
Google Scholar
Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, Klickstein L, Aggarwal P, Nemirovskiy O, Byrjalsen I, Qvist P, Bay-Jensen AC, Dam EB, Madsen SH, Christiansen C: Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development. Biomarkers. 2009, 14 (3): 181-202.
CAS
PubMed
Google Scholar
Veidal SS, Vassiliadis E, Barascuk N, Zhang C, Segovia-Silvestre T, Klickstein L, Larsen MR, Qvist P, Christiansen C, Vainer B, Karsdal MA: Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis. Liver Int. 2010, 30 (9): 1293-1304.
CAS
PubMed
Google Scholar
Bay-Jensen AC, Liu Q, Byrjalsen I, Li Y, Wang J, Pedersen C, Leeming DJ, Dam EB, Zheng Q, Qvist P, Karsdal MA: Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM–increased serum CIIM in subjects with severe radiographic osteoarthritis. Clin Biochem. 2011, 44 (5–6): 423-429.
CAS
PubMed
Google Scholar
Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, Duffin KL: Characterization of metalloprotease cleavage products of human articular cartilage. Arthritis Rheum. 2008, 58 (8): 2420-2431.
CAS
PubMed
Google Scholar
Skjot-Arkil H, Clausen RE, Nguyen QH, Wang Y, Zheng Q, Martinez FJ, Hogaboam CM, Han M, Klickstein LB, Larsen MR, Nawrocki A, Leeming DJ, Karsdal MA: Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC Pulm Med. 2012, 12: 34.
PubMed Central
PubMed
Google Scholar
Blaauboer ME, Emson CL, Verschuren L, van Erk M, Turner SM, Everts V, Hanemaaijer R, Stoop R: Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways. Matrix Biol. 2013, Epub ahead of print
Google Scholar