Sternlicht MD, Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001, 17: 463-516. 10.1146/annurev.cellbio.17.1.463.
Article
PubMed Central
CAS
PubMed
Google Scholar
Overall CM, Blobel CP: In search of partners: linking extracellular proteases to substrates. Nat Rev Mol Cell Biol. 2007, 8: 245-257. 10.1038/nrm2120.
Article
CAS
PubMed
Google Scholar
Martin MD, Matrisian LM: The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev. 2007, 26: 717-724. 10.1007/s10555-007-9089-4.
Article
CAS
PubMed
Google Scholar
Hemmann S, Graf J, Roderfeld M, Roeb E: Expression of MMPs and TIMPs in liver fibrosis: a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol. 2007, 46: 955-975. 10.1016/j.jhep.2007.02.003.
Article
CAS
PubMed
Google Scholar
Steffensen B, Wallon UM, Overall CM: Extracellular matrix binding properties of recombinant fibronectin type II-like modules of human 72-kDa gelatinase/type IV collagenase: high affinity binding to native type I collagen but not native type IV collagen. J Biol Chem. 1995, 270: 11555-11566. 10.1074/jbc.270.19.11555.
Article
CAS
PubMed
Google Scholar
Aimes RT, Quigley JP: Matrix metalloproteinase-2 is an interstitial collagenase: inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem. 1995, 270: 5872-5876. 10.1074/jbc.270.11.5872.
Article
CAS
PubMed
Google Scholar
Gehrmann ML, Douglas JT, Banyai L, Tordai H, Patthy L, Llinas M: Modular autonomy, ligand specificity, and functional cooperativity of the three in-tandem fibronectin type II repeats from human matrix metalloproteinase 2. J Biol Chem. 2004, 279: 46921-46929. 10.1074/jbc.M408859200.
Article
CAS
PubMed
Google Scholar
Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB: The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. J Biol Chem. 2006, 281: 38302-38313. 10.1074/jbc.M606004200.
Article
CAS
PubMed
Google Scholar
Bjorklund M, Koivunen E: Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta. 2005, 1755: 37-69.
PubMed
Google Scholar
Stefanidakis M, Koivunen E: Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression. Blood. 2006, 108: 1441-1450. 10.1182/blood-2006-02-005363.
Article
CAS
PubMed
Google Scholar
Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M: The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol. 2009, 386: 419-434. 10.1016/j.jmb.2008.12.021.
Article
CAS
PubMed
Google Scholar
Robinet A, Emonard H, Banyai L, Laronze J-Y, Patthy L, Hornebeck W, Bellon G: Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion. Life Sci. 2008, 82: 376-382. 10.1016/j.lfs.2007.11.018.
Article
CAS
PubMed
Google Scholar
Steffensen B, Bigg HF, Overall CM: The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activation. J Biol Chem. 1998, 273: 20622-20628. 10.1074/jbc.273.32.20622.
Article
CAS
PubMed
Google Scholar
Ellerbroek SM, Wu YI, Stack MS: Type I collagen stabilization of matrix metalloproteinase-2. Arch Biochem Biophys. 2001, 390: 51-56. 10.1006/abbi.2001.2345.
Article
CAS
PubMed
Google Scholar
Freise C, Erben U, Muche M, Farndale R, Zeitz M, Somasundaram R, Ruehl M: The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity. Matrix Biol. 2009, 28: 480-489. 10.1016/j.matbio.2009.08.001.
Article
CAS
PubMed
Google Scholar
Ottl J, Gabriel D, Murphy G, Knauper V, Tominaga Y, Nagase H, Kroger M, Tschesche H, Bode W, Moroder L: Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chem Biol. 2000, 7: 119-132. 10.1016/S1074-5521(00)00077-6.
Article
CAS
PubMed
Google Scholar
Xu X, Chen Z, Wang Y, Bonewald L, Steffensen B: Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions. Biochem J. 2007, 406: 147-155. 10.1042/BJ20070591.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhou X, Hovell CJ, Pawley S, Hutchings MI, Arthur MJ, Iredale JP, Benyon RC: Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int. 2004, 24: 492-501. 10.1111/j.1478-3231.2004.0946.x.
Article
CAS
PubMed
Google Scholar
Watanabe T, Niioka M, Ishikawa A, Hozawa S, Arai M, Maruyama K, Okada A, Okazaki I: Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat. J Hepatol. 2001, 35: 465-473. 10.1016/S0168-8278(01)00177-5.
Article
CAS
PubMed
Google Scholar
Fuke H, Saitou Y, Nakano T, Uemoto S, Shiraki K: Matrix metalloproteinase, hepatocyte growth factor, and tissue inhibitor of matrix metalloproteinase during human liver regeneration. Liver Int. 2006, 26: 380-381. 10.1111/j.1478-3231.2005.01237.x.
Article
CAS
PubMed
Google Scholar
Feige JJ, Baird A: Crinopexy: extracellular regulation of growth factor action. Kidney Int Suppl. 1995, 49: S15-S18.
CAS
PubMed
Google Scholar
Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, Lopez-Otin C, Seth A: Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biol Chem. 2004, 385: 493-504. 10.1515/BC.2004.058.
Article
CAS
PubMed
Google Scholar
Nyberg P, Xie L, Kalluri R: Endogenous inhibitors of angiogenesis. Cancer Res. 2005, 65: 3967-3979. 10.1158/0008-5472.CAN-04-2427.
Article
CAS
PubMed
Google Scholar
Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K: Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science. 1999, 284: 1667-1670. 10.1126/science.284.5420.1667.
Article
CAS
PubMed
Google Scholar
Briknarova K, Gehrmann M, Banyai L, Tordai H, Patthy L, Llinas M: Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct. J Biol Chem. 2001, 276: 27613-27621. 10.1074/jbc.M101105200.
Article
CAS
PubMed
Google Scholar
Banyai L, Tordai H, Patthty L: Structure and domain-domain interactions of the gelatin binding site of human 72-kilodalton type IV collagenase (gelatinase A, matrix metalloproteinase 2). J Biol Chem. 1996, 271: 12003-12008. 10.1074/jbc.271.20.12003.
Article
CAS
PubMed
Google Scholar
Bigg HF, Rowan AD, Barker MD, Cawston TE: Activity of matrix metalloproteinase-9 against native collagen types I and III. FEBS J. 2007, 274: 1246-1255. 10.1111/j.1742-4658.2007.05669.x.
Article
CAS
PubMed
Google Scholar
Persikov AV, Ramshaw JA, Brodsky B: Prediction of collagen stability from amino acid sequence. J Biol Chem. 2005, 280: 19343-19349. 10.1074/jbc.M501657200.
Article
CAS
PubMed
Google Scholar
Allan JA, Docherty AJ, Barker PJ, Huskisson NS, Reynolds JJ, Murphy G: Binding of gelatinases A and B to type-I collagen and other matrix components. Biochem J. 1995, 309: 299-306.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kar K, Amin P, Bryan MA, Persikov AV, Mohs A, Wang YH, Brodsky B: Self-association of collagen triple helic peptides into higher order structures. J Biol Chem. 2006, 281: 33283-33290. 10.1074/jbc.M605747200.
Article
CAS
PubMed
Google Scholar
Rossi A, Zuccarello LV, Zanaboni G, Monzani E, Dyne KM, Cetta G, Tenni R: Type I collagen CNBr peptides: species and behavior in solution. Biochemistry. 1996, 35: 6048-6057. 10.1021/bi9518151.
Article
CAS
PubMed
Google Scholar
Smethurst PA, Onley DJ, Jarvis GE, O'Connor MN, Knight CG, Herr AB, Ouwehand WH, Farndale RW: Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets. J Biol Chem. 2007, 282: 1296-1304. 10.1074/jbc.M606479200.
Article
CAS
PubMed
Google Scholar
Lebbink RJ, de Ruiter T, Adelmeijer J, Brenkman AB, van Helvoort JM, Koch M, Farndale RW, Lisman T, Sonnenberg A, Lenting PJ, Meyaard L: Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1. J Exp Med. 2006, 203: 1419-1425. 10.1084/jem.20052554.
Article
PubMed Central
CAS
PubMed
Google Scholar
Overall CM: Matrix metalloproteinase substrate binding domains, modules and exosites: overview and experimental strategies. Methods Mol Biol. 2001, 151: 79-120.
CAS
PubMed
Google Scholar
Jani M, Tordai H, Trexler M, Banyai L, Patthy L: Hydroxamate-based peptide inhibitors of matrix metalloprotease 2. Biochimie. 2005, 87: 385-392. 10.1016/j.biochi.2004.09.008.
Article
CAS
PubMed
Google Scholar
Bannikov GA, Karelina TV, Collier IE, Marmer BL, Goldberg GI: Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide. J Biol Chem. 2002, 277: 16022-16027. 10.1074/jbc.M110931200.
Article
CAS
PubMed
Google Scholar
Xu X, Wang Y, Lauer-Fields JL, Fields GB, Steffensen B: Contributions of the MMP-2 collagen binding domain to gelatin cleavage: substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides. Matrix Biol. 2004, 23: 171-181. 10.1016/j.matbio.2004.05.002.
Article
CAS
PubMed
Google Scholar
Fingleton B: MMPs as therapeutic targets: still a viable option?. Semin Cell Dev Biol. 2008, 19: 61-68. 10.1016/j.semcdb.2007.06.006.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lauer-Fields JL, Whitehead JK, Li S, Hammer RP, Brew K, Fields GB: Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition. J Biol Chem. 2008, 283: 20087-20095. 10.1074/jbc.M801438200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sela-Passwell N, Rosenblum G, Shoham T, Sagi I: Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition?. Biochim Biophys Acta. 2010, 1803: 29-38. 10.1016/j.bbamcr.2009.04.010.
Article
CAS
PubMed
Google Scholar
Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D: Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFκB. J Biol Chem. 2006, 281: 15090-15098. 10.1074/jbc.M600030200.
Article
CAS
PubMed
Google Scholar
Howard EW, Bullen EC, Banda MJ: Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2. J Biol Chem. 1991, 266: 13064-13069.
CAS
PubMed
Google Scholar
Bergmann U, Tuuttila A, Stetler-Stevenson WG, Tryggvason K: Autolytic activation of recombinant human 72 kilodalton type IV collagenase. Biochemistry. 1995, 34: 2819-2825. 10.1021/bi00009a011.
Article
CAS
PubMed
Google Scholar
Will H, Atkinson SJ, Butler GS, Smith B, Murphy G: The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3. J Biol Chem. 1996, 271: 17119-17123. 10.1074/jbc.271.29.17124.
Article
CAS
PubMed
Google Scholar
Ruehl M, Somasundaram R, Schoenfelder I, Farndale RW, Knight CG, Schmid M, Ackermann R, Riecken EO, Zeitz M, Schuppan D: The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. J Biol Chem. 2002, 277: 26872-26878. 10.1074/jbc.M202335200.
Article
CAS
PubMed
Google Scholar
Matsudaira P: Limited N-terminal sequence analysis. Methods Enzymol. 1990, 182: 602-613. full_text.
Article
CAS
PubMed
Google Scholar
Knight CG, Morton LF, Onley DJ, Peachey AR, Ichinohe T, Okuma M, Farndale RW, Barnes MJ: Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen. Cardiovasc Res. 1999, 41: 450-457. 10.1016/S0008-6363(98)00306-X.
Article
CAS
PubMed
Google Scholar
Erat MC, Slatter DA, Lowe ED, Millard CJ, Farndale RW, Campbell ID, Vakonakis I: Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. Proc Natl Acad Sci USA. 2009, 106: 4195-4200. 10.1073/pnas.0812516106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Frederiks WM, Mook OR: Metabolic mapping of proteinase activity with emphasis on in situ zymography of gelatinases: review and protocols. J Histochem Cytochem. 2004, 52: 711-722. 10.1369/jhc.4R6251.2004.
Article
CAS
PubMed
Google Scholar
Mook OR, Van Overbeek C, Ackema EG, Van Maldegem F, Frederiks WM: In situ localization of gelatinolytic activity in the extracellular matrix of metastases of colon cancer in rat liver using quenched fluorogenic DQ-gelatin. J Histochem Cytochem. 2003, 51: 821-829.
Article
CAS
PubMed
Google Scholar
Xu Y, Gurusiddappa S, Rich RL, Owens RT, Keene DR, Mayne R, Hook A, Hook M: Multiple binding sites in collagen type I for the integrins α1β1 and α2β1. J Biol Chem. 2000, 275: 38981-38989. 10.1074/jbc.M007668200.
Article
CAS
PubMed
Google Scholar
Knight CG, Willenbrock F, Murphy G: A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases. FEBS Lett. 1992, 296: 263-266. 10.1016/0014-5793(92)80300-6.
Article
CAS
PubMed
Google Scholar