Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G: The myofibroblast: one function, multiple origins. Am J Pathol. 2007, 170: 1807-1816. 10.2353/ajpath.2007.070112.
Article
PubMed Central
CAS
PubMed
Google Scholar
Leask A, Abraham DJ: TGFβ signaling and the fibrotic response. FASEB J. 2004, 18: 816-827. 10.1096/fj.03-1273rev.
Article
CAS
PubMed
Google Scholar
Ramirez F, Tanaka S, Bou-Gharios G: Transcriptional regulation of the human β2 (I) collagen gene (COL1A2), an informative model system to study fibrotic diseases. Matrix Biol. 2006, 25: 365-372. 10.1016/j.matbio.2006.05.002.
Article
CAS
PubMed
Google Scholar
Shi Y, Massagué J: Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 2003, 63: 515-524.
Google Scholar
Moustakas A, Heldin CH: Non-Smad TGF-β signals. J Cell Sci. 2005, 118: 3573-3584. 10.1242/jcs.02554.
Article
CAS
PubMed
Google Scholar
Geiser AG, Kim SJ, Roberts AB, Sporn MB: Characterization of the mouse transforming growth factor-β1 promoter and activation by the Ha-ras oncogene. Mol Cell Biol. 1991, 11: 84-92.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD: Transforming growth factor-β1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem. 2000, 275: 6628-6635. 10.1074/jbc.275.9.6628.
Article
CAS
PubMed
Google Scholar
Phanish MK, Wahab NA, Hendry BM, Dockrell ME: TGF-β1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signaling. Nephron Exp Nephrol. 2005, 100: e156-e165. 10.1159/000085445.
Article
PubMed
Google Scholar
Stratton R, Rajkumar V, Ponticos M, Nichols B, Shiwen X, Black CM, Abraham DJ, Leask A: Prostacyclin derivatives prevent the fibrotic response to TGF-β by inhibiting the Ras/MEK/ERK pathway. FASEB J. 2002, 16: 1949-1951.
CAS
PubMed
Google Scholar
Suzuki K, Wilkes MC, Garamszegi N, Edens M, Leof EB: Transforming growth factor β signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses. Cancer Res. 2007, 67: 3673-3682. 10.1158/0008-5472.CAN-06-3211.
Article
CAS
PubMed
Google Scholar
Thatcher JD: The Ras-MAPK signal transduction pathway. Sci Signal. 2010, 3: trl1.
Google Scholar
Ohtsu H, Suzuki H, Nakashima H, Dhobale S, Frank GD, Motley ED, Eguchi S: Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells. Hypertension. 2006, 48: 534-540. 10.1161/01.HYP.0000237975.90870.eb.
Article
CAS
PubMed
Google Scholar
Satoh T, Fantl WJ, Escobedo JA, Williams LT, Kaziro Y: Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. Mol Cell Biol. 1993, 13: 3706-3713.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lander HM, Hajjar DP, Hempstead BL, Mirza UA, Chait BT, Campbell S, Quilliam LA: A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. J Biol Chem. 1997, 272: 4323-4326. 10.1074/jbc.272.28.17810.
Article
CAS
PubMed
Google Scholar
Baroni SS, Santillo M, Bevilacqua F, Luchetti M, Spadoni T, Mancini M, Fraticelli P, Sambo P, Kazlauskas A, Avvedimento EV, Gabrielli A: Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med. 2006, 354: 2667-2676. 10.1056/NEJMoa052955.
Article
CAS
PubMed
Google Scholar
Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Santillo M, Cuozzo C, et al: Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem. 2005, 280: 3674-36782. 10.1074/jbc.M502851200.
Article
Google Scholar
Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates TGFβ1 stimulation of β2(I) collagen (COL1A2) transcription. J Biol Chem. 2000, 275: 39237-39245. 10.1074/jbc.M003339200.
Article
CAS
PubMed
Google Scholar
Fedorova E, Battini L, Prakash-Cheng A, Marras D, Gusella GL: Lentiviral gene delivery to CNS by spinal intrathecal administration to neonatal mice. J Gene Med. 2006, 8: 414-424. 10.1002/jgm.861.
Article
CAS
PubMed
Google Scholar
Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB: An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem. 1994, 216: 276-284. 10.1006/abio.1994.1042.
Article
CAS
PubMed
Google Scholar
Fleming YM, Ferguson GJ, Spender LC, Larsson J, Karlsson S, Ozanne BW, Grosse R, Inman GJ: TGFβ-mediated activation of RhoA signaling is required for efficient V12HaRas and V600EBRAF transformation. Oncogene. 2009, 28: 983-993. 10.1038/onc.2008.449.
Article
CAS
PubMed
Google Scholar
Mori Y, Chen SJ, Varga J: Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum. 2003, 48: 1964-1978. 10.1002/art.11157.
Article
CAS
PubMed
Google Scholar
Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF: Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling. Genes Dev. 2008, 22: 106-120. 10.1101/gad.1590908.
Article
PubMed Central
CAS
PubMed
Google Scholar
Massagué J: G1 cell-cycle control and cancer. Nature. 2004, 432: 298-306.
Article
PubMed
Google Scholar
Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A: GSK-3β in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest. 2008, 118: 3279-3290. 10.1172/JCI35381R1.
Article
PubMed Central
CAS
PubMed
Google Scholar
Daly AC, Vizan P, Hill CS: Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-β responses. J Biol Chem. 2010, 285: 6489-6497. 10.1074/jbc.M109.043877.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kretzschmar M, Doody J, Timokhina I, Massagué J: A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev. 1999, 13: 804-816. 10.1101/gad.13.7.804.
Article
PubMed Central
CAS
PubMed
Google Scholar
Slack JL, Parker MI, Robinson VR, Bornstein P: Regulation of collagen I gene expression by ras. Mol Cell Biol. 1992, 12: 4714-4723.
Article
PubMed Central
CAS
PubMed
Google Scholar