Hay ED: The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Developmental Dynamics. 2005, 233: 706-720. 10.1002/dvdy.20345.
Article
CAS
PubMed
Google Scholar
Kalluri R, Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 2009, 119: 1420-1428. 10.1172/JCI39104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thiery JP, Acloque H, Huang RY, Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 2009, 139: 871-890. 10.1016/j.cell.2009.11.007.
Article
CAS
PubMed
Google Scholar
Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995, 130: 393-405. 10.1083/jcb.130.2.393.
Article
CAS
PubMed
Google Scholar
Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest. 2002, 110: 341-350.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R: BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003, 9: 964-968. 10.1038/nm888.
Article
CAS
PubMed
Google Scholar
Faulkner JL, Szcykalski LM, Springer F, Barnes JL: Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am J Pathol. 2005, 167: 1193-1205. 10.1016/S0002-9440(10)61208-4.
Article
PubMed Central
CAS
PubMed
Google Scholar
Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS: Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010, 176: 85-97. 10.2353/ajpath.2010.090517.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeisberg M, Duffield JS: Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol. 2010, 21: 1247-1253. 10.1681/ASN.2010060616.
Article
PubMed
Google Scholar
Ross MH, Romrell LJ, Kaye GI: Histology. A text and atlas. 1995
Google Scholar
Hertig A, Flier SN, Kalluri R: Contribution of epithelial plasticity to renal transplantation-associated fibrosis. Transplant Proc. 2010, 42: S7-12. 10.1016/j.transproceed.2010.07.040.
Article
PubMed Central
CAS
PubMed
Google Scholar
Essawy M, Soylemezoglu O, Muchaneta-Kubara EC, Shortland J, Brown CB, el Nahas AM: Myofibroblasts and the progression of diabetic nephropathy. Nephrol Dial Transplant. 1997, 12: 43-50. 10.1093/ndt/12.1.43.
Article
CAS
PubMed
Google Scholar
Giannico G, Yang H, Neilson EG, Fogo AB: Dystroglycan in the diagnosis of FSGS. Clin J Am Soc Nephrol. 2009, 4: 1747-1753. 10.2215/CJN.01510209.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nishitani Y, Iwano M, Yamaguchi Y, Harada K, Nakatani K, Akai Y, Nishino T, Shiiki H, Kanauchi M, Saito Y, Neilson EG: Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int. 2005, 68: 1078-1085. 10.1111/j.1523-1755.2005.00500.x.
Article
CAS
PubMed
Google Scholar
Scherer A, Gwinner W, Mengel M, Kirsch T, Raulf F, Szustakowski JD, Hartmann N, Staedtler F, Engel G, Klupp J, et al: Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months. Nephrol Dial Transplant. 2009, 24: 2567-2575. 10.1093/ndt/gfp183.
Article
CAS
PubMed
Google Scholar
Rodder S, Scherer A, Raulf F, Berthier CC, Hertig A, Couzi L, Durrbach A, Rondeau E, Marti HP: Renal allografts with IF/TA display distinct expression profiles of metzincins and related genes. Am J Transplant. 2009, 9: 517-526. 10.1111/j.1600-6143.2008.02512.x.
Article
CAS
PubMed
Google Scholar
Einecke G, Reeve J, Sis B, Mengel M, Hidalgo L, Famulski KS, Matas A, Kasiske B, Kaplan B, Halloran PF: A molecular classifier for predicting future graft loss in late kidney transplant biopsies. J Clin Invest. 2010, 120: 1862-1872. 10.1172/JCI41789.
Article
PubMed Central
CAS
PubMed
Google Scholar
Muthukumar T, Ding R, Snopkowski C, Hummel A, Sharma VK, Dadhania D, Seshan S, Suthanthiran M, Anglicheau D: Noninvasive diagnosis of renal interstitial fibrosis and tubular atrophy (IF/TA) by measurement of epithelial to mesenchymal transition (EMT) genes in urine. American Journal of Transplantation. 2009, 9: 226-227.
Google Scholar
Le Hir M, Hegyi I, Cueni-Loffing D, Loffing J, Kaissling B: Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol. 2005, 123: 335-346. 10.1007/s00418-005-0788-z.
Article
CAS
PubMed
Google Scholar
Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG: Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int. 2000, 58: 587-597. 10.1046/j.1523-1755.2000.00205.x.
Article
CAS
PubMed
Google Scholar
Osterreicher CH, Penz-Osterreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA: Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci USA. 2011, 108: 308-313. 10.1073/pnas.1017547108.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gibbs FE, Barraclough R, Platt-Higgins A, Rudland PS, Wilkinson MC, Parry EW: Immunocytochemical distribution of the calcium-binding protein p9Ka in normal rat tissues: variation in the cellular location in different tissues. J Histochem Cytochem. 1995, 43: 169-180. 10.1177/43.2.7822773.
Article
CAS
PubMed
Google Scholar
Inoue T, Plieth D, Venkov CD, Xu C, Neilson EG: Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int. 2005, 67: 2488-2493. 10.1111/j.1523-1755.2005.00358.x.
Article
PubMed
Google Scholar
Flatmark K, Maelandsmo GM, Mikalsen SO, Nustad K, Varaas T, Rasmussen H, Meling GI, Fodstad O, Paus E: Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum. Tumour Biol. 2004, 25: 31-40. 10.1159/000077721.
Article
CAS
PubMed
Google Scholar
Grigorian M, Tulchinsky E, Burrone O, Tarabykina S, Georgiev G, Lukanidin E: Modulation of mts1 expression in mouse and human normal and tumor cells. Electrophoresis. 1994, 15: 463-468. 10.1002/elps.1150150163.
Article
CAS
PubMed
Google Scholar
Cabezon T, Celis JE, Skibshoj I, Klingelhofer J, Grigorian M, Gromov P, Rank F, Myklebust JH, Maelandsmo GM, Lukanidin E, Ambartsumian N: Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer. Int J Cancer. 2007, 121: 1433-1444. 10.1002/ijc.22850.
Article
CAS
PubMed
Google Scholar
Okada H, Danoff TM, Kalluri R, Neilson EG: Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol. 1997, 273: F563-574.
CAS
PubMed
Google Scholar
Schneider M, Hansen JL, Sheikh SP: S100A4: a common mediator of epithelial-mesenchymal transition, fibrosis and regeneration in diseases?. J Mol Med. 2008, 86: 507-522. 10.1007/s00109-007-0301-3.
Article
CAS
PubMed
Google Scholar
Boye K, Maelandsmo GM: S100A4 and metastasis: a small actor playing many roles. Am J Pathol. 2010, 176: 528-535. 10.2353/ajpath.2010.090526.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hertig A, Verine J, Mougenot B, Jouanneau C, Ouali N, Sebe P, Glotz D, Ancel PY, Rondeau E, Xu-Dubois YC: Risk factors for early epithelial to mesenchymal transition in renal grafts. American Journal of Transplantation. 2006, 6: 2937-2946. 10.1111/j.1600-6143.2006.01559.x.
Article
CAS
PubMed
Google Scholar
Zeisberg M, Neilson EG: Biomarkers for epithelial-mesenchymal transitions. Journal of Clinical Investigation. 2009, 119: 1429-1437. 10.1172/JCI36183.
Article
PubMed Central
CAS
PubMed
Google Scholar
Prozialeck WC, Lamar PC, Appelt DM: Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron. BMC Physiol. 2004, 4: 10-10.1186/1472-6793-4-10.
Article
PubMed Central
PubMed
Google Scholar
Robertson D, Savage K, Reis-Filho JS, Isacke CM: Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. BMC Cell Biol. 2008, 9: 13-10.1186/1471-2121-9-13.
Article
PubMed Central
PubMed
Google Scholar
Mendez MG, Kojima S, Goldman RD: Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. Faseb J. 2010, 24: 1838-1851. 10.1096/fj.09-151639.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, et al: Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011, 30: 457-470. 10.1038/onc.2010.421.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D: Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One. 2010, 5: e10105-10.1371/journal.pone.0010105.
Article
PubMed Central
PubMed
Google Scholar
Wei J, Xu G, Wu M, Zhang Y, Li Q, Liu P, Zhu T, Song A, Zhao L, Han Z, et al: Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation. Anticancer Res. 2008, 28: 327-334.
CAS
PubMed
Google Scholar
Eckes B, Colucci-Guyon E, Smola H, Nodder S, Babinet C, Krieg T, Martin P: Impaired wound healing in embryonic and adult mice lacking vimentin. J Cell Sci. 2000, 113 (Pt 13): 2455-2462.
CAS
PubMed
Google Scholar
Terzi F, Henrion D, Colucci-Guyon E, Federici P, Babinet C, Levy BI, Briand P, Friedlander G: Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance. J Clin Invest. 1997, 100: 1520-1528. 10.1172/JCI119675.
Article
PubMed Central
CAS
PubMed
Google Scholar
Terzi F, Maunoury R, Colucci-Guyon E, Babinet C, Federici P, Briand P, Friedlander G: Normal tubular regeneration and differentiation of the post-ischemic kidney in mice lacking vimentin. Am J Pathol. 1997, 150: 1361-1371.
PubMed Central
CAS
PubMed
Google Scholar
Maretta M, Marettova E: Immunohistochemical demonstration of vimentin and S-100 protein in the kidneys. Gen Physiol Biophys. 1999, 18 (Suppl 1): 100-102.
PubMed
Google Scholar
Holthofer H, Miettinen A, Lehto VP, Lehtonen E, Virtanen I: Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys. Lab Invest. 1984, 50: 552-559.
CAS
PubMed
Google Scholar
Grone HJ, Weber K, Grone E, Helmchen U, Osborn M: Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol. 1987, 129: 1-8.
PubMed Central
CAS
PubMed
Google Scholar
Witzgall R, Brown D, Schwarz C, Bonventre JV: Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest. 1994, 93: 2175-2188. 10.1172/JCI117214.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jinde K, Nikolic-Paterson DJ, Huang XR, Sakai H, Kurokawa K, Atkins RC, Lan HY: Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis. Am J Kidney Dis. 2001, 38: 761-769. 10.1053/ajkd.2001.27693.
Article
CAS
PubMed
Google Scholar
Rastaldi MP, Ferrario F, Giardino L, Dell'Antonio G, Grillo C, Grillo P, Strutz F, Muller GA, Colasanti G, D'Amico G: Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int. 2002, 62: 137-146. 10.1046/j.1523-1755.2002.00430.x.
Article
PubMed
Google Scholar
Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF: Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant. 2005, 5: 1367-1374. 10.1111/j.1600-6143.2005.00843.x.
Article
CAS
PubMed
Google Scholar
He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y: Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol. 2009, 20: 765-776. 10.1681/ASN.2008060566.
Article
PubMed Central
CAS
PubMed
Google Scholar
He W, Kang YS, Dai C, Liu Y: Blockade of Wnt/{beta}-Catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol. 2011, 22: 90-103. 10.1681/ASN.2009121236.
Article
PubMed Central
CAS
PubMed
Google Scholar
Surendran K, Schiavi S, Hruska KA: Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol. 2005, 16: 2373-2384. 10.1681/ASN.2004110949.
Article
CAS
PubMed
Google Scholar
von Toerne C, Schmidt C, Adams J, Kiss E, Bedke J, Porubsky S, Gretz N, Lindenmeyer MT, Cohen CD, Grone HJ, Nelson PJ: Wnt pathway regulation in chronic renal allograft damage. Am J Transplant. 2009, 9: 2223-2239. 10.1111/j.1600-6143.2009.02762.x.
Article
CAS
PubMed
Google Scholar
Hertig A, Bonnard G, Ulinski T, Colombat M, Jouanneau C, Baugey E, Bensman A, Ronco P, Rondeau E, Xu-Dubois Y-C: Tubular nuclear accumulation of snail and epithelial phenotypic changes in human myeloma cast nephropathy. Human Pathology. 2011
Google Scholar
Brenner BM: The Kidney. 2008, 1: 995-996.
Google Scholar
Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, Harada K, Kubo A, Akai Y, Toyoda M, Kanauchi M, et al: Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis. 2009, 54: 653-664. 10.1053/j.ajkd.2009.05.009.
Article
CAS
PubMed
Google Scholar
Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, et al: Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant. 2008, 8: 753-760. 10.1111/j.1600-6143.2008.02159.x.
Article
CAS
PubMed
Google Scholar
Vitalone MJ, O'Connell PJ, Jimenez-Vera E, Yuksel A, Wavamunno M, Fung CL, Chapman JR, Nankivell BJ: Epithelial-to-mesenchymal transition in early transplant tubulointerstitial damage. J Am Soc Nephrol. 2008, 19: 1571-1583. 10.1681/ASN.2007050580.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hertig A, Anglicheau D, Verine J, Pallet N, Touzot M, Ancel PY, Mesnard L, Brousse N, Baugey E, Glotz D, et al: Early Epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol. 2008
Google Scholar
de Matos AC, Camara NO, Tonato EJ, Durao Junior Mde S, Franco MF, Moura LA, Pacheco-Silva A: Vimentin expression and myofibroblast infiltration are early markers of renal dysfunction in kidney transplantation: an early stage of chronic allograft dysfunction?. Transplant Proc. 2010, 42: 3482-3488. 10.1016/j.transproceed.2010.06.014.
Article
PubMed
Google Scholar
Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003, 112: 1776-1784.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu Y: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol. 2010, 21: 212-222. 10.1681/ASN.2008121226.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thiery JP, Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006, 7: 131-142. 10.1038/nrm1835.
Article
CAS
PubMed
Google Scholar
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, Csiszar K, Fong KS, Vega S, Nieto MA, Cano A, Portillo F: A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. Embo J. 2005, 24: 3446-3458. 10.1038/sj.emboj.7600781.
Article
PubMed Central
CAS
PubMed
Google Scholar
Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, et al: Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest. 2007, 117: 3810-3820.
PubMed Central
CAS
PubMed
Google Scholar
Sun S, Ning X, Zhang Y, Lu Y, Nie Y, Han S, Liu L, Du R, Xia L, He L, Fan D: Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. Kidney Int. 2009, 75: 1278-1287. 10.1038/ki.2009.62.
Article
CAS
PubMed
Google Scholar
Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol. 2002, 13: 96-107.
CAS
PubMed
Google Scholar
Reese S, Vidyasagar A, Jacobson L, Acun Z, Esnault S, Hullett D, Malter JS, Djamali A: The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010, 3: 1-10.1186/1755-1536-3-1.
Article
PubMed Central
PubMed
Google Scholar
Hills CE, Squires PE: TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am J Nephrol. 2009, 31: 68-74. 10.1159/000256659.
Article
PubMed
Google Scholar
Bedi S, Vidyasagar A, Djamali A: Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando). 2008, 22: 1-5.
Article
PubMed Central
PubMed
Google Scholar