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Table 1 Expression and biological roles of angiogenic factors in health and CKD

From: Angiogenesis and chronic kidney disease

  Healthy kidney Human CKD (non-diabetic) Diabetic nephropathy Therapeutic effects
VEGF-A Podocyte (h, m, r),
TEC (h)
Decreased (renal) Decreased (h),
Increased (h, m, r)
Anti-Thy1 nephritis (r), anti-GBM nephritis (r), thrombotic microangiopathy (r), remnant kidney (r)
VEGFR-1 GEnC (h, m), PTC (h) MC (Mesangio-proliferative GN) NE NE
VEGFR-2 GEnC (h, m), podocyte (m), MC (h), PTC (h) MC (Mesangio-proliferative GN) Increased (r) NE
sVEGFR-1 NE Increased: pre-eclampsia, CKD (serum) NE Diabetic nephropathy (m)
Neuropilin-1 GEnC (h), podocyte (h), MC (h), TEC (m) NE NE NE
Ang-1 podocyte (h, m) Decreased: CKD (serum) Decreased (r; renal) Obstructive uropathy (m), diabetic nephropathy (m)
Ang-2 TEC (m) Increased: CKD (serum) Increased (h; serum),
increased (r, m; renal)
  1. Ang-1 = angiopoietin-1; Ang-2 = angiopoietin-2; CKD = chronic kidney disease; GEnC = glomerular endothelial cells; GBM = glomerular basement membrane; GN = glomerulonephritis; h = human; m = mouse; MC = mesangial cell; NE = not examined; PTC = peritubular capillaries; r = rat; TEC = tubular epithelial cells.