Table 1 Expression and biological roles of angiogenic factors in health and CKD

VEGF-A

Podocyte (h, m, r),

TEC (h)

Decreased (renal)

Decreased (h),

Increased (h, m, r)

Anti-Thy1 nephritis (r), anti-GBM nephritis (r), thrombotic microangiopathy (r), remnant kidney (r)

VEGFR-1

GEnC (h, m), PTC (h)

MC (Mesangio-proliferative GN)

NE

NE

VEGFR-2

GEnC (h, m), podocyte (m), MC (h), PTC (h)

MC (Mesangio-proliferative GN)

Increased (r)

NE

sVEGFR-1

NE

Increased: pre-eclampsia, CKD (serum)

NE

Diabetic nephropathy (m)

Neuropilin-1

GEnC (h), podocyte (h), MC (h), TEC (m)

NE

NE

NE

Ang-1

podocyte (h, m)

Decreased: CKD (serum)

Decreased (r; renal)

Obstructive uropathy (m), diabetic nephropathy (m)

Ang-2

TEC (m)

Increased: CKD (serum)

Increased (h; serum),

increased (r, m; renal)

NE