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Table 1 Summary of cell derived factors in different cell populations.

From: Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis

Stem cell type

Stem-cell derived factors

Bone marrow

 

   BM-MNCs

VEGF, bFGF, Ang-1, IL-1β, TNF-α [26]

   BMSCs (HSCs and MSCs)

VEGF, bFGF, IGF, SDF-1, Akt, eNOS [27]

   MSCs

VEGF, bFGF, Ang-1, IL-1, SDF-1, PIGF, MCP-1, FGF-7, IL-6, TGF-β, PDGF, PA, MMP-9, TB4, Sfrp, Tenacin C, Thrombospondin-1 [28, 29]

   MAPCs

VEGF, MCP-1, TGF- β, PDGF-BB [32]

   Multipotent BM-derived cells (non-HSCs and non-MSCs)

VEGF, bFGF, Ang-1, Ang-2, IGF-1, SDF-1α, PDGF-B, HGF [34]

Circulating

 

   Cultured PB-MNCs

VEGF, HGF, G-CSF, GM-CSF [35]

   EPCs

VEGF-A, VEGF-B, SDF-1, IGF-1 [72]; VEGF-A FGF-2, IGF-1, HGF, Ang-1, SDF-1 [36]

Tissue resident

 

   Cardiac stem cells

 

   c-kit+, MDR-1+, Sca-1+

IGF-1, HGF [71]

   Adipose stem cells

MMP-9, MMP-3 [82]; VEGF, HGF, TGF-β [83, 84]