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Table 2 Composition of interstitial fluid in tumors

From: Interstitial fluid: the overlooked component of the tumor microenvironment?

Tumor type

Host

Protein, mg/ml

COP, mm Hg

pH

Lactic acid, mg/l

Reference

  

TIF

Subcutis

Plasma

TIF

Subcutis

Plasma

TIF

Plasma (arterial)

TIF

Plasma

 

Carcinoma (Walker 256)

Rat

32 ± 1

41 ± 2

48 ± 1

   

7.044 ±0.044

7.313 ± 0.041

16.1 ± 1.1

9.5 ± 0.9

[41, 95]

Mammary carcinoma

Mouse

54

 

55 - 60

       

[40]

Carcinoma (Walker 256)

Rat

      

6.98 ± 0.13

 

15

15

[70]

Colon adenocarcinoma (LS174T)

Mouse

   

16.7 ± 3.0

      

[43]

Small cell lung carcinoma (54A)

    

21.1 ± 2.8

8.2 ±2.3

20.0 ± 1.6

     

Mammary carcinoma (chemically induced)

Rat

44.7

 

54.9

16.6 ± 1.0

13.8 ±1.0

20.5 ±0.8

    

[61]

  1. COP: Colloid osmotic pressure, TIF: Tumor interstitial fluid. Empty cells in table: Value not determined