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  1. Research

    Matrix and cell phenotype differences in Dupuytren’s disease

    Dupuytren’s disease is a fibroproliferative disease of the hand and fingers, which usually manifests as two different phenotypes within the same patient. The disease first causes a nodule in the palm of the ha...

    Marike M. van Beuge, Evert-Jan P. M. ten Dam, Paul M. N. Werker and Ruud A. Bank

    Fibrogenesis & Tissue Repair 2016 9:9

    Published on: 29 June 2016

  2. Research

    Activation of hepatic stellate cell in Pten null liver injury model

    Hepatic fibrosis is a prominent pathological feature associated with chronic liver disease including non-alcoholic hepatosteatosis (NASH), and a precursor for liver cancer development. We previously reported t...

    Lina He, James Gubbins, Zhechu Peng, Vivian Medina, Fan Fei, Kinji Asahina, Jiaohong Wang, Michael Kahn, Carl B. Rountree and Bangyan L. Stiles

    Fibrogenesis & Tissue Repair 2016 9:8

    Published on: 14 June 2016

  3. Research

    Age-dependent development of liver fibrosis in Glmp gt/gt mice

    Mice lacking glycosylated lysosomal membrane protein (Glmp gt/gt mice) have liver fibrosis as the predominant phenotype due to chronic liver inju...

    Cecilie K. Nesset, Xiang Yi Kong, Markus Damme, Camilla Schjalm, Norbert Roos, Else Marit Løberg and Winnie Eskild

    Fibrogenesis & Tissue Repair 2016 9:5

    Published on: 28 April 2016

  4. Research

    Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis

    Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows the tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can ...

    Robert M. DiFazio, Joshua T. Mattila, Edwin C. Klein, Lauren R. Cirrincione, Mondraya Howard, Eileen A. Wong and JoAnne L. Flynn

    Fibrogenesis & Tissue Repair 2016 9:6

    Published on: 27 April 2016

  5. Research

    Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice

    Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation an...

    Jennifer M. McCracken, Lu Jiang, Krutika T. Deshpande, Maura F. O’Neil and Michele T. Pritchard

    Fibrogenesis & Tissue Repair 2016 9:4

    Published on: 31 March 2016

  6. Review

    Biomaterials for hollow organ tissue engineering

    Tissue engineering is a rapidly advancing field that is likely to transform how medicine is practised in the near future. For hollow organs such as those found in the cardiovascular and respiratory systems or ...

    Eseelle K. Hendow, Pauline Guhmann, Bernice Wright, Panagiotis Sofokleous, Nina Parmar and Richard M. Day

    Fibrogenesis & Tissue Repair 2016 9:3

    Published on: 23 March 2016

  7. Research

    Transcriptomic analysis of the effects of Toll-like receptor 4 and its ligands on the gene expression network of hepatic stellate cells

    Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of TLR4 signaling on the gene expression net...

    Yangyang Ouyang, Jinsheng Guo, Chenzhao Lin, Jie Lin, Yirong Cao, Yuanqin Zhang, Yujin Wu, Shiyao Chen, Jiyao Wang, Luonan Chen and Scott L. Friedman

    Fibrogenesis & Tissue Repair 2016 9:2

    Published on: 18 February 2016

  8. Review

    Dipeptidyl peptidase-4 and kidney fibrosis in diabetes

    Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Recent eviden...

    Sen Shi, Daisuke Koya and Keizo Kanasaki

    Fibrogenesis & Tissue Repair 2016 9:1

    Published on: 13 February 2016

  9. Research

    Thromboxane promotes smooth muscle phenotype commitment but not remodeling of hypoxic neonatal pulmonary artery

    Persistent pulmonary hypertension of the newborn (PPHN) is characterized by vasoconstriction and pulmonary vascular remodeling. Remodeling is believed to be a response to physical or chemical stimuli including...

    Fabiana Postolow, Jena Fediuk, Nora Nolette, Martha Hinton and Shyamala Dakshinamurti

    Fibrogenesis & Tissue Repair 2015 8:20

    Published on: 1 November 2015

  10. Research

    Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

    Macrophages play critical roles in liver regeneration, fibrosis development and resolution. They are among the first responders to liver injury and are implicated in orchestrating the fibrogenic response via m...

    Katharine M. Irvine, Andrew D. Clouston, Victoria L. Gadd, Gregory C. Miller, Weng-Yew Wong, Michelle Melino, Muralidhara Rao Maradana, Kelli MacDonald, Richard A. Lang, Matthew J. Sweet, Antje Blumenthal and Elizabeth E. Powell

    Fibrogenesis & Tissue Repair 2015 8:19

    Published on: 15 October 2015

  11. Research

    L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice

    Hepatic fibrosis, which is the excessive accumulation of extracellular matrices (ECMs) produced mainly from activated hepatic stellate cells (HSCs), develops to cirrhosis over several decades. There are no val...

    Mitsuko Hara, Ikuyo Inoue, Yuta Yamazaki, Akiko Kirita, Tomokazu Matsuura, Scott L. Friedman, Daniel B. Rifkin and Soichi Kojima

    Fibrogenesis & Tissue Repair 2015 8:17

    Published on: 15 September 2015

  12. Research

    Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling

    Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised ...

    Louise Catherine Stone, Lorna Susan Thorne, Christopher John Weston, Mark Graham and Nikolas John Hodges

    Fibrogenesis & Tissue Repair 2015 8:15

    Published on: 21 August 2015

  13. Research

    In vitro reversion of activated primary human hepatic stellate cells

    Liver fibrosis is characterized by the excessive formation and accumulation of matrix proteins as a result of wound healing in the liver. A main event during fibrogenesis is the activation of the liver residen...

    Adil El Taghdouini, Mustapha Najimi, Pau Sancho-Bru, Etienne Sokal and Leo A. van Grunsven

    Fibrogenesis & Tissue Repair 2015 8:14

    Published on: 6 August 2015

  14. Research

    Novel approach for the detection of tubular cell migration into the interstitium during renal fibrosis in rats

    The process of epithelial-mesenchymal transition (EMT), which is generally defined by phenotypic changes of injured tubules such as loss of epithelial markers or acquisition of mesenchymal markers, implies var...

    Masao Nakasatomi, Akito Maeshima, Keiichiro Mishima, Hidekazu Ikeuchi, Toru Sakairi, Yoriaki Kaneko, Keiju Hiromura and Yoshihisa Nojima

    Fibrogenesis & Tissue Repair 2015 8:12

    Published on: 10 July 2015

  15. Research

    Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1

    A major health disparity suffered by African Americans (AA) is a predisposition toward fibrotic diseases of the skin, lung, and other organs. We previously showed that healthy AA and scleroderma (systemic scle...

    Rebecca Lee, Charles Reese, Beth Perry, Jonathan Heywood, Michael Bonner, Marina Zemskova, Richard M. Silver, Stanley Hoffman and Elena Tourkina

    Fibrogenesis & Tissue Repair 2015 8:11

    Published on: 20 June 2015

  16. Research

    Pentoxifylline immunomodulation in the treatment of experimental chronic pulmonary paracoccidioidomycosis

    Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties. The simultaneous use of PTX and antifungal therapy (itraconazole) has previously been evaluated in an experi...

    Damaris Elena Lopera, Tonny Williams Naranjo, José Miguel Hidalgo, Laura Echeverri, Jairo Hernando Patiño, Ángela Restrepo Moreno, Henrique Leonel Lenzi and Luz Elena Cano

    Fibrogenesis & Tissue Repair 2015 8:10

    Published on: 1 June 2015

  17. Review

    Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration

    Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the symptoms of many human diseases have been reversed in animal models with iPSC therapy, setting the stage for future clinical developmen...

    Ana Belen Alvarez Palomo, Samuel McLenachan, Fred K Chen, Lyndon Da Cruz, Rodney J Dilley, Jordi Requena, Michaela Lucas, Andrew Lucas, Micha Drukker and Michael J Edel

    Fibrogenesis & Tissue Repair 2015 8:9

    Published on: 15 May 2015

  18. Research

    Donor caveolin 1 (CAV1) genetic polymorphism influences graft function after renal transplantation

    Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the dis...

    Cynthia Van der Hauwaert, Grégoire Savary, Claire Pinçon, Viviane Gnemmi, Christian Noël, Franck Broly, Myriam Labalette, Michaël Perrais, Nicolas Pottier, François Glowacki and Christelle Cauffiez

    Fibrogenesis & Tissue Repair 2015 8:8

    Published on: 5 May 2015

  19. Review

    Modulation of angiotensin II signaling in the prevention of fibrosis

    Over the last decade, it has become clear that the role of angiotensin II extends far beyond recognized renal and cardiovascular effects. The presence of an autologous renin-angiotensin system has been demonst...

    Amanda M Murphy, Alison L Wong and Michael Bezuhly

    Fibrogenesis & Tissue Repair 2015 8:7

    Published on: 23 April 2015

  20. Research

    Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca2+-dependent and regulated by KCa3.1 K+ channels

    Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K+ channel KCa3.1 reduces constitutive α-SMA and Smad2/3 nuclear tran...

    Katy M Roach, Carol Feghali-Bostwick, Heike Wulff, Yassine Amrani and Peter Bradding

    Fibrogenesis & Tissue Repair 2015 8:5

    Published on: 26 March 2015

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