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  1. Content type: Research

    Idiopathic arthrofibrosis occurs in 3-4% of patients who undergo total knee arthroplasty (TKA). However, little is known about the cellular or molecular changes involved in the onset or progression of this con...

    Authors: Theresa A Freeman, Javad Parvizi, Craig J Dela Valle and Marla J Steinbeck

    Citation: Fibrogenesis & Tissue Repair 2010 3:17

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  2. Content type: Review

    Pirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnorma...

    Authors: José Macías-Barragán, Ana Sandoval-Rodríguez, Jose Navarro-Partida and Juan Armendáriz-Borunda

    Citation: Fibrogenesis & Tissue Repair 2010 3:16

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  3. Content type: Review

    Bioartificial kidneys (BAKs) combine a conventional hemofilter in series with a bioreactor unit containing renal epithelial cells. The epithelial cells derived from the renal tubule should provide transport, m...

    Authors: Farah Tasnim, Rensheng Deng, Min Hu, Sean Liour, Yao Li, Ming Ni, Jackie Y Ying and Daniele Zink

    Citation: Fibrogenesis & Tissue Repair 2010 3:14

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  4. Content type: Review

    The number of patients requiring renal replacement therapy due to end-stage renal disease (ESRD) is increasing worldwide. The prevalence of chronic kidney disease (CKD), and the importance of CKD as a risk fac...

    Authors: Yohei Maeshima and Hirofumi Makino

    Citation: Fibrogenesis & Tissue Repair 2010 3:13

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  5. Content type: Short review

    The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the inte...

    Authors: Helge Wiig, Olav Tenstad, Per Ole Iversen, Raghu Kalluri and Rolf Bjerkvig

    Citation: Fibrogenesis & Tissue Repair 2010 3:12

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  6. Content type: Research

    To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model.

    Authors: Lynne A Murray, Michael S Kramer, David P Hesson, Brynmor A Watkins, Edward G Fey, Rochelle L Argentieri, Furquan Shaheen, Darryl A Knight and Stephen T Sonis

    Citation: Fibrogenesis & Tissue Repair 2010 3:11

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  7. Content type: Research

    Computer-based morphometry can minimize subjectivity in the assessment of liver fibrosis. An image processing program was developed with Delphi for the quantification of fibrosis in liver tissue samples staine...

    Authors: Sebastian Huss, Jörg Schmitz, Diane Goltz, Hans-Peter Fischer, Reinhard Büttner and Ralf Weiskirchen

    Citation: Fibrogenesis & Tissue Repair 2010 3:10

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  8. Content type: Research

    Tendon disorders (tendinopathies) pose serious biomedical and socioeconomic problems. Despite diverse treatment approaches, the best treatment strategy remains unclear. Surgery remains the last resort because ...

    Authors: Jean-Paul Courneya, Irina G Luzina, Cynthia B Zeller, Jeffrey F Rasmussen, Alexander Bocharov, Lew C Schon and Sergei P Atamas

    Citation: Fibrogenesis & Tissue Repair 2010 3:9

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  9. Content type: Review

    Chronic kidney diseases share common pathogenic mechanisms that, independently from the initial injury, lead to glomerular hyperfiltration, proteinuria, and progressive renal scarring and function loss. Inhibi...

    Authors: Irene M van der Meer, Paolo Cravedi and Giuseppe Remuzzi

    Citation: Fibrogenesis & Tissue Repair 2010 3:7

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  10. Content type: Research

    Fibrosis can be described as the excess deposition of extracellular matrix (ECM) components, such as collagens and proteoglycans. Fibrosis of the liver, which eventually leads to cirrhosis, is a major global h...

    Authors: Sanne Skovgård Veidal, Efstathios Vassiliadis, Anne-Christine Bay-Jensen, Gervais Tougas, Ben Vainer and Morten Asser Karsdal

    Citation: Fibrogenesis & Tissue Repair 2010 3:5

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  11. Content type: Review

    Regulation of cellular functions during dermal repair following injury is complex and critically dependent on the interaction of cells with the surrounding extracellular matrix (ECM). The ECM comprises various...

    Authors: Beate Eckes, Roswitha Nischt and Thomas Krieg

    Citation: Fibrogenesis & Tissue Repair 2010 3:4

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  12. Content type: Research

    Expression of insulin-like growth factor binding protein 5 (IGFBP5) is strongly induced upon activation of hepatic stellate cells and their transdifferentiation into myofibroblasts in vitro. This was confirmed in...

    Authors: Aleksandar Sokolović, Milka Sokolović, Willem Boers, Ronald PJ Oude Elferink and Piter J Bosma

    Citation: Fibrogenesis & Tissue Repair 2010 3:3

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  13. Content type: Research

    Defective epithelial repair, excess fibroblasts and myofibroblasts, collagen overproduction and fibrosis occur in a number of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) a...

    Authors: Joana Câmara and Gabor Jarai

    Citation: Fibrogenesis & Tissue Repair 2010 3:2

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  14. Content type: Research

    Pin 1 is a peptidyl-prolyl isomerase inhibitor related to cyclophilin A and FK506 binding protein (FKBP). Juglone (5-hydroxy-1,4-naphthoquinone) is a natural inhibitor of Pin 1 with anti-inflammatory and antif...

    Authors: Shannon Reese, Aparna Vidyasagar, Lynn Jacobson, Zeki Acun, Stephane Esnault, Debra Hullett, James S Malter and Arjang Djamali

    Citation: Fibrogenesis & Tissue Repair 2010 3:1

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  15. Content type: Review

    Fibrosis can occur in tissues in response to a variety of stimuli. Following tissue injury, cells undergo transformation or activation from a quiescent to an activated state resulting in tissue remodelling. Th...

    Authors: Georgina L Hold, Paraskevi Untiveros, Karin A Saunders and Emad M El-Omar

    Citation: Fibrogenesis & Tissue Repair 2009 2:6

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  16. Content type: Research

    Arthrofibrosis, occurring in 3%-4% of patients following total knee arthroplasty (TKA), is a challenging condition for which there is no defined cause. The hypothesis for this study was that disregulated produ...

    Authors: Theresa A Freeman, Javad Parvizi, Craig J Della Valle and Marla J Steinbeck

    Citation: Fibrogenesis & Tissue Repair 2009 2:5

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  17. Content type: Short review

    Human chronic liver diseases (CLDs) with different aetiologies rely on chronic activation of wound healing that represents the driving force for fibrogenesis progression (throughout defined patterns of fibrosi...

    Authors: Maurizio Parola and Massimo Pinzani

    Citation: Fibrogenesis & Tissue Repair 2009 2:4

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  18. Content type: Review

    In most adult epithelia the process of replacing damaged or dead cells is maintained through the presence of stem/progenitor cells, which allow epithelial tissues to be repaired following injury. Existing evid...

    Authors: Paola Romagnani and Raghu Kalluri

    Citation: Fibrogenesis & Tissue Repair 2009 2:3

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  19. Content type: Research

    Regression of hepatic fibrosis in patients with autoimmune hepatitis (AIH) has been described in response to immunosuppressive therapy. These studies, however, besides being few in number, were conducted on ad...

    Authors: Ahmed F Abdalla, Khaled R Zalata, Abeer F Ismail, Gamal Shiha, Mohamed Attiya and Ahmed Abo-Alyazeed

    Citation: Fibrogenesis & Tissue Repair 2009 2:2

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  20. Content type: Research

    Human hepatic stellate cells have been shown to be resistant to apoptotic stimuli. This is likely dependent on the activation of anti-apoptotic pathways upon transition of these cells to myofibroblast-like cel...

    Authors: Alessandra Gentilini, Benedetta Lottini, Marco Brogi, Alessandra Caligiuri, Lorenzo Cosmi, Fabio Marra and Massimo Pinzani

    Citation: Fibrogenesis & Tissue Repair 2009 2:1

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  21. Content type: Research

    Erythropoietin possesses cellular protection properties. The aim of the present study was to test the hypothesis that in situ expression of recombinant human erythropoietin (rhEPO) would improve tissue repair in ...

    Authors: Emil Ruvinov, Orna Sharabani-Yosef, Arnon Nagler, Tom Einbinder, Micha S Feinberg, Radka Holbova, Amos Douvdevani and Jonathan Leor

    Citation: Fibrogenesis & Tissue Repair 2008 1:7

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  22. Content type: Review

    Obstructive cholestasis causes hepatic cirrhosis and portal hypertension. The pathophysiological mechanisms involved in the development of liver disease are multiple and linked. We propose grouping these mecha...

    Authors: María-Angeles Aller, Jorge-Luis Arias, Jose García-Domínguez, Jose-Ignacio Arias, Manuel Durán and Jaime Arias

    Citation: Fibrogenesis & Tissue Repair 2008 1:6

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  23. Content type: Research

    In skin, connective tissue growth factor (CTGF/CCN2) is induced during tissue repair. However, what the exact cell types are that express CTGF in normal and wounded skin remain controversial. In this report, w...

    Authors: Mohit Kapoor, Shangxi Liu, Kun Huh, Sunil Parapuram, Laura Kennedy and Andrew Leask

    Citation: Fibrogenesis & Tissue Repair 2008 1:3

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