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  1. Content type: Research

    Idiopathic pulmonary fibrosis is a disease characterized by alveolar epithelial cell injury, inflammatory cell infiltration and deposition of extracellular matrix in lung tissue. As mouse models of bleomycin-i...

    Authors: Lisa Honeyman, Mark Bazett, Tomasz G Tomko and Christina K Haston

    Citation: Fibrogenesis & Tissue Repair 2013 6:16

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  2. Content type: Research

    Myofibroblasts play a crucial role in tissue repair. The functional similarities and differences between myofibroblasts and fibroblasts are not fully understood because they have not been separately isolated f...

    Authors: Taisuke Akamatsu, Yosifumi Arai, Isao Kosugi, Hideya Kawasaki, Shiori Meguro, Makiko Sakao, Kiyoshi Shibata, Takafumi Suda, Kingo Chida and Toshihide Iwashita

    Citation: Fibrogenesis & Tissue Repair 2013 6:15

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  3. Content type: Research

    Interleukin (IL)-17A and IL-17E (also known as IL-25) have been implicated in fibrosis in various tissues. However, the role of these cytokines in the development of intestinal strictures in Crohn’s disease (C...

    Authors: Paolo Biancheri, Sylvia LF Pender, Francesca Ammoscato, Paolo Giuffrida, Gianluca Sampietro, Sandro Ardizzone, Amir Ghanbari, Renata Curciarello, Alessandra Pasini, Giovanni Monteleone, Gino R Corazza, Thomas T MacDonald and Antonio Di Sabatino

    Citation: Fibrogenesis & Tissue Repair 2013 6:13

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  4. Content type: Research

    Fibrosis poses a substantial setback in regenerative medicine. Histopathologically, fibrosis is an excessive accumulation of collagen affected by myofibroblasts and this can occur in any tissue that is exposed...

    Authors: Ariel Bing-Shi Tan, Sebastian Kress, Leticia Castro, Allan Sheppard and Michael Raghunath

    Citation: Fibrogenesis & Tissue Repair 2013 6:12

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  5. Content type: Research

    Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF rec...

    Authors: Johanna Donovan, Xu Shiwen, Jill Norman and David Abraham

    Citation: Fibrogenesis & Tissue Repair 2013 6:10

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  6. Content type: Research

    The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases which involve dysregulated ex...

    Authors: Federica Genovese, Natasha Barascuk, Lise Larsen, Martin Røssel Larsen, Arkadiusz Nawrocki, Yili Li, Qinlong Zheng, Jianxia Wang, Sanne Skovgård Veidal, Diana Julie Leeming and Morten Asser Karsdal

    Citation: Fibrogenesis & Tissue Repair 2013 6:9

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  7. Content type: Research

    Wound healing involves complex mechanisms, which, if properly chaperoned, can enhance patient recovery. The abilities of platelets and keratinocytes may be harnessed in order to stimulate wound healing through...

    Authors: Samia Guerid, Salim E Darwiche, Mette M Berger, Lee Ann Applegate, Messod Benathan and Wassim Raffoul

    Citation: Fibrogenesis & Tissue Repair 2013 6:8

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  8. Content type: Research

    Cyclosporin A (CsA), an immunosuppressive agent modifies the wound healing process through an influence on extracellular matrix metabolism. We have compared the effects of CsA on dermal fibroblasts from nude (...

    Authors: Barbara Gawronska-Kozak and Heather Kirk-Ballard

    Citation: Fibrogenesis & Tissue Repair 2013 6:7

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  9. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a poorly understood progressive disease characterized by the recurrent damage of alveolar epithelial cells as well as inappropriate expansion and activation of fibroblast...

    Authors: Saiko Shibata and Junichi Ishiyama

    Citation: Fibrogenesis & Tissue Repair 2013 6:6

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  10. Content type: Research

    Crew members on space missions inevitably are exposed to low background radiation and can receive much higher doses during solar particle events (SPE) that consist primarily of protons. Ionizing radiation coul...

    Authors: Jian Tian, Sisi Tian and Daila S Gridley

    Citation: Fibrogenesis & Tissue Repair 2013 6:4

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  11. Content type: Meeting Report

    The 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4 to 5, 2012 informed about pathophysiological mechanisms in tissue repair and on the development of clinical treatments of c...

    Authors: Boris Hinz, Magda Ulrich, Hilde Beele and Dimitris Kletsas

    Citation: Fibrogenesis & Tissue Repair 2013 6:3

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  12. Content type: Research

    The extravasation of granulocytes (such as neutrophils) at a site of inflammation is a key aspect of the innate immune system. Signals from the site of inflammation upregulate granulocyte adhesion to the endot...

    Authors: Anu S Maharjan, David Roife, Derrick Brazill and Richard H Gomer

    Citation: Fibrogenesis & Tissue Repair 2013 6:2

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  13. Content type: Review

    Histone deacetylase (HDAC) inhibitors have been extensively studied in experimental models of cancer, where their inhibition of deacetylation has been proven to regulate cell survival, proliferation, different...

    Authors: Katrien Van Beneden, Inge Mannaerts, Marina Pauwels, Christiane Van den Branden and Leo A van Grunsven

    Citation: Fibrogenesis & Tissue Repair 2013 6:1

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  14. Content type: Review

    Adult stem cells are activated to proliferate and differentiate during normal tissue homeostasis as well as in disease states and injury. This activation is a vital component in the restoration of function to ...

    Authors: Thavaneetharajah Pretheeban, Dario R Lemos, Benjamin Paylor, Regan-Heng Zhang and Fabio M Rossi

    Citation: Fibrogenesis & Tissue Repair 2012 5:20

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  15. Content type: Research

    The possibility of extracting RNA and measuring RNA expression from paraffin sections can allow extensive investigations on stored paraffin samples obtained from diseased livers and could help with studies of ...

    Authors: Nicholas R Staten, Eric A Welsh, Kurex Sidik, Sandra A McDonald, Dawn R Dufield, Botoul Maqsodi, Yunqing Ma, Gary K McMaster, Rodney W Mathews, Robert H Arch, Jaime L Masferrer and Bernard E Souberbielle

    Citation: Fibrogenesis & Tissue Repair 2012 5:21

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  16. Content type: Research

    Combined pulmonary fibrosis and emphysema (CPFE) is characterized by both emphysema of the upper zone and diffuse parenchymal lung disease with fibrosis of the lower zone of the lung on chest computed tomograp...

    Authors: Masayuki Hanaoka, Michiko Ito, Yunden Droma, Atsuhito Ushiki, Yoshiaki Kitaguchi, Masanori Yasuo and Keishi Kubo

    Citation: Fibrogenesis & Tissue Repair 2012 5:17

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  17. Content type: Review

    Following myocardial infarction, wound healing takes place in the infarct area where the non-viable cardiac tissue is replaced by a scar. Inadequate wound healing or insufficient maintenance of the extracellul...

    Authors: Kevin CM Hermans, Evangelos P Daskalopoulos and W Matthijs Blankesteijn

    Citation: Fibrogenesis & Tissue Repair 2012 5:16

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  18. Content type: Review

    Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, w...

    Authors: Ling Xu, Keizo Kanasaki, Munehiro Kitada and Daisuke Koya

    Citation: Fibrogenesis & Tissue Repair 2012 5:13

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  19. Content type: Research

    miRNAs are non-coding RNAs that regulate gene expression in a wide range of biological contexts, including a variety of diseases. The present study clarified the role of miR-214-5p in hepatic fibrogenesis usin...

    Authors: Masashi Iizuka, Tomohiro Ogawa, Masaru Enomoto, Hiroyuki Motoyama, Katsutoshi Yoshizato, Kazuo Ikeda and Norifumi Kawada

    Citation: Fibrogenesis & Tissue Repair 2012 5:12

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  20. Content type: Review

    Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most ...

    Authors: Nevins W Todd, Irina G Luzina and Sergei P Atamas

    Citation: Fibrogenesis & Tissue Repair 2012 5:11

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  21. Content type: Review

    ‘Augmenter of liver regeneration’ (ALR) (also known as hepatic stimulatory substance or hepatopoietin) was originally found to promote growth of hepatocytes in the regenerating or injured liver. ALR is express...

    Authors: Chandrashekhar R Gandhi

    Citation: Fibrogenesis & Tissue Repair 2012 5:10

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  22. Content type: Research

    Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis. This can result in reduced ventricular compliance, diastolic d...

    Authors: Chris J Watson, Dermot Phelan, Maojia Xu, Patrick Collier, Roisin Neary, Albert Smolenski, Mark Ledwidge, Kenneth McDonald and John Baugh

    Citation: Fibrogenesis & Tissue Repair 2012 5:9

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  23. Content type: Proceedings

    A discrepancy between oxygen availability and demand has been found in most chronic kidney diseases (CKD) irrespective of etiology. This results from a combination of structural and functional changes that are...

    Authors: Volker H Haase

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S16

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    This article is part of a Supplement: Volume 5 Supplement 1

  24. Content type: Proceedings

    This review provides an introduction to mass spectrometry based proteomics and discusses several proteomics approaches that are relevant in understanding the pathophysiology of fibrotic disorders and the appro...

    Authors: Marjan Gucek

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S10

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    This article is part of a Supplement: Volume 5 Supplement 1

  25. Content type: Proceedings

    Lung fibrosis is the final common pathway of a large variety of chronic lung disorders, named interstitial lung diseases. The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by al...

    Authors: Annie Pardo and Moisés Selman

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S9

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    This article is part of a Supplement: Volume 5 Supplement 1

  26. Content type: Proceedings

    The overall aim of presented study is to test the inhibition of the formation of collagen fibrils as the novel approach to reduce accumulation of pathological fibrotic deposits. The main hypothesis is that by ...

    Authors: Andrzej Steplewski and Andrzej Fertala

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S29

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    This article is part of a Supplement: Volume 5 Supplement 1

  27. Content type: Proceedings

    Several recent studies have demonstrated that endothelial to mesenchymal transition (EndoMT), a newly recognized type of cellular transdifferentiation may be an important source of myofibroblasts during the de...

    Authors: Sonsoles Piera-Velazquez and Sergio A Jimenez

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S7

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    This article is part of a Supplement: Volume 5 Supplement 1

  28. Content type: Proceedings

    Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. When tissues are damaged, tissue homeostasis must be r...

    Authors: Ludovic Micallef, Nicolas Vedrenne, Fabrice Billet, Bernard Coulomb, Ian A Darby and Alexis Desmoulière

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S5

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    This article is part of a Supplement: Volume 5 Supplement 1

  29. Content type: Proceedings

    Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Al...

    Authors: Naoki Iwamoto and Oliver Distler

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S19

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    This article is part of a Supplement: Volume 5 Supplement 1

  30. Content type: Proceedings

    A subset of myeloproliferative disorders (MPN) and myelodyplastic syndromes (MDS) evolves to fibrosis of the bone marrow associated with haematopoietic insufficiency. We have been interested in chemokines invo...

    Authors: Hans Kreipe, Guntram Büsche, Oliver Bock and Kais Hussein

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S21

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    This article is part of a Supplement: Volume 5 Supplement 1

  31. Content type: Proceedings

    The vasculature of the kidney is a heterogeneous structure, whose functional integrity is essential for the regulation of renal function. Owing to the importance of the endothelium in vascular biology, chronic...

    Authors: Dominique Guerrot, Jean-Claude Dussaule, Panagiotis Kavvadas, Jean-Jacques Boffa, Christos E Chadjichristos and Christos Chatziantoniou

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S15

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  32. Content type: Proceedings

    Chronic toxicities of locoregional and systemic oncological treatments commonly develop in long-term cancer survivors. Amongst these toxicities, post-radiotherapeutic complications alter patient's quality of l...

    Authors: Saad Hamama, Sylvie Delanian, Virginie Monceau and Marie-Catherine Vozenin

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S13

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    This article is part of a Supplement: Volume 5 Supplement 1

  33. Content type: Proceedings

    The wound-healing process induced by chronic hepatitis C virus (HCV) infection triggers liver damage characterized by fibrosis development and finally cirrhosis. Liver Transplantation (LT) is the optimal surgi...

    Authors: Ricardo Gehrau, Valeria Mas, Kellie Archer and Daniel Maluf

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S11

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  34. Content type: Proceedings

    Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are active in tumor-r...

    Authors: Annica Jacobson and Janet L Cunningham

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S8

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  35. Content type: Proceedings

    The dynamic process of epithelial-to-mesenchymal transition (EMT) is a causal event in kidney fibrosis. This cellular phenotypic transition involves activation of transcriptional responses and remodeling of ce...

    Authors: Shreyasi Das, Bryan N Becker, F Michael Hoffmann and Janet E Mertz

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S28

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    This article is part of a Supplement: Volume 5 Supplement 1

  36. Content type: Proceedings

    Activated hepatic stellate cells (HSC) play a central role in scar formation that leads to liver fibrosis. The molecular mechanisms underlying this process are not fully understood. Microarray and bioinformati...

    Authors: Hideaki Shimada and Lakshman E Rajagopalan

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S12

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    This article is part of a Supplement: Volume 5 Supplement 1

  37. Content type: Proceedings

    Bone marrow fibrosis is a hallmark of primary and post ET/PV myelofibrosis. To investigated the impact of replacement of the hematopoietic system in myelofibrosis patients by allogeneic stem cell transplantati...

    Authors: Nicolaus Kröger, Michael Kvasnicka and Jürgen Thiele

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S25

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    This article is part of a Supplement: Volume 5 Supplement 1

  38. Content type: Proceedings

    Novel approaches are needed to define subgroups of patients with Idiopathic pulmonary fibrosis (IPF) at risk for acute exacerbations and/or accelerated progression of this generally fatal disease. Progression ...

    Authors: Cory M Hogaboam, Glenda Trujillo and Fernando J Martinez

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S3

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    This article is part of a Supplement: Volume 5 Supplement 1

  39. Content type: Proceedings

    A common feature of pathological fibrosis involving the lung and other organs is the persistent activation of myofibroblasts in injured tissues. Recent evidence supports the role of a member of the NADPH oxida...

    Authors: Victor J Thannickal

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S23

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

  40. Content type: Proceedings

    Most chronic liver diseases of all etiologies result in progressive liver fibrosis. Myofibroblasts produce the extracellular matrix, including type I collagen, which constitutes the fibrous scar in liver fibro...

    Authors: David A Brenner, Tatiana Kisseleva, David Scholten, Yong Han Paik, Keiko Iwaisako, Sayaka Inokuchi, Bernd Schnabl, Ekihiro Seki, Samuele De Minicis, Christoph Oesterreicher and Kojiro Taura

    Citation: Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S17

    Published on:

    This article is part of a Supplement: Volume 5 Supplement 1

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