Fig. 7
From: Activation of hepatic stellate cell in Pten null liver injury model
Activation of β-catenin leads to the activation of HSCs. a. Expression of Wnt ligands Wnt5a, 7a, 7b, and 10a in control (Con), Pten null (Pm), and Pten/Akt2 double mutant (Dm) livers. *significantly different from the control groups of the same gene at p < 0.05. n = 3. b Expression of Wnt 5a alternative receptor sFRP5 in the control (Con, open bar) and Pten null liver (solid bar). *significantly different from the control groups of the same gene at p < 0.05. n = 5. Cultured human HSCs were treated with sFRP, and expression of fibrogenic genes was evaluated (c, d). c Survivin expression indicating that sFRP treatment reduced β-catenin transcriptional activity. d Expression of fibrogenic genes. *significantly different from the control groups of the same gene at p < 0.05. n = 3