Fig. 1
From: Activation of hepatic stellate cell in Pten null liver injury model
Association of fibrosis and PTEN status with NASH. a Sirius Red staining for fibrosis in biopsied liver human non-alcoholic steatohepatitis (NASH) patients. Biopsy livers were obtained from patients with various degrees of diagnosed NASH. Sirius Red staining is performed on the livers to identify fibrotic regions. Top two panels, fibrosis near fatty liver deposits; bottom up second panel, premalignant lesions with intensive Sirius Red staining; bottom panel, areas with fibrotic tissues only. Right panels, higher magnified images of the cropped areas from the left panels. Arrows: lipid deposit in hepatocytes. Dotted enclosure, premalignant lesion. b PTEN expression is lower in NASH vs. control samples. Publically available data set (GSE37031) was analyzed for expression of PTEN. *p < 0.05. c Immunohistochemical analysis of PTEN protein in two patients. Images generated by The Human Protein Atlas (www.proteinatlas.org)