TY - JOUR AU - Miguel, Verónica AU - Busnadiego, Oscar AU - Fierro-Fernández, Marta AU - Lamas, Santiago PY - 2016 DA - 2016/05/10 TI - Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblasts JO - Fibrogenesis & Tissue Repair SP - 7 VL - 9 IS - 1 AB - Excessive accumulation of extracellular matrix (ECM) proteins is the hallmark of fibrotic diseases, including skin fibrosis. This response relies on the activation of dermal fibroblasts that evolve into a pro-fibrogenic phenotype. One of the major players in this process is the cytokine transforming growth factor-β (TGF-β). MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression affecting a wide range of pathophysiological events including fibrogenesis. MicroRNA-9-5p (miR-9-5p) has been shown to exert a protective role in lung and peritoneal fibrosis. This study aimed to evaluate the role of miR-9-5p in skin fibrosis. SN - 1755-1536 UR - https://doi.org/10.1186/s13069-016-0044-2 DO - 10.1186/s13069-016-0044-2 ID - Miguel2016 ER -