Fig. 5

Biochemical evidence of TGFβ and collagen. a ELISA for active TGFβ. TGFβ in granulomas was converted into pg and then normalized by the total amount of protein in each granuloma as determined by BCA assay. Wilcoxon signed-rank test was used to compare granulomas from active disease to granulomas from 2 months of drug treatment. b Hydroxyproline assay. Collagen present in granulomas was determined using the hydroxyproline assay. Values were converted into pg and then normalized by the total amount of protein in each granuloma as determined by BCA assay