Fig. 1

Expression of GLMP in wild-type mice and analysis of the Glmp ^gt/gt phenotype. Wild-type (WT) and Glmp ^gt/gt mice were sacrificed at designated time-points from newborn to 9 months of age, and their livers were extracted. a Expression of mRNA for GLMP at different time-points was measured by qPCR. b Representative images of WT and Glmp ^gt/gt livers from selected time-points. Scale bar 1 cm. c Paraffin-embedded liver sections from WT and Glmp ^gt/gt mice from age-matched mice, stained with hematoxylin and eosin, revealed extramedullar hematopoiesis (arrows) and infiltration of inflammatory cells (arrowheads). Scale bar 100 μm