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Fig. 6 | Fibrogenesis & Tissue Repair

Fig. 6

From: Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice

Fig. 6

Hepatic fibrotic marker transcript accumulation and plasma HA levels after chronic CCl4 exposure. The mice were exposed to CCl4 for 5 weeks, twice per week, and were euthanized 72 h after the final CCl4 exposure. Control animals received olive oil (oil) injections. Hepatic a Acta2, b Col1a1, and c Col1a2 transcript accumulation was determined using real-time PCR. The data are expressed as fold change over each strain’s olive oil-treated control after normalization to 18S. d HA concentration was determined using an HA ELISA-like assay (see the “Methods” section for details). e Hepatic Has enzyme transcript levels in wild-type and Has3−/− mice. Data were normalized to Has1 levels in wild-type mice at baseline. N = 5–6 mice per experimental group. nd not detected, i.e., transcripts were below the level of detection, n/a not applicable. *P < 0.05 compared between genotypes

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