Table 7 Venn analysis for pathways of differentially expressed genes belong to both LPS and HMGB1 treatment in JS1 cells vs JS2 cells, and the key regulatory genes
Pathway ID | Pathway term | Enrichment (+, up; −, down) | P value | No. of DifGenes | Gene-act-net core genes (degree >5) |
|---|---|---|---|---|---|
PATH:03420 | Nucleotide excision repair | 4.6978 | 0.0308 | 3 | Pold2 |
PATH:00010 | Glycolysis/gluconeogenesis | 4.3364 | 0.0171 | 4 | Hk1 |
PATH:03040 | Spliceosome | 3.5744 | 0.0052 | 7 | Ddx39b |
PATH:04110 | Cell cycle | 2.7963 | 0.0403 | 5 | TRP53, Ccnd2 |
PATH:00230 | Purine metabolism | 2.4022 | 0.0476 | 6 | Pde2a, Polr2f, Ak2 |
PATH:04010 | MAPK signaling pathway | −3.3387 | 0.0133 | 6 | Prkca, Map3k1, Hspb1 |
PATH:04141 | Protein processing in endoplasmic reticulum | −4.4615 | 0.0075 | 5 | Eif2s1 |
PATH:04120 | Ubiquitin-mediated proteolysis | −5.3857 | 0.0035 | 5 | Map3k1 |