Table 5 Venn-analysis for pathways of differentially expressed genes that were LPS responsive only in JS1 cells vs JS2 cells and the key regulatory genes
Pathway ID | Pathway term | Enrichment | P value | No. of DifGenes | Gene-act-net |
|---|---|---|---|---|---|
(+, up; −, down) | core genes (degree >5) | ||||
PATH:04668 | TNF signaling pathway | 3.8644 | 0.0005 | 10 | Mapk9, Mapk14, Map2k1 |
PATH:04722 | Neurotrophin signaling pathway | 3.7442 | 0.0002 | 12 | Mapk9, Foxo3, Mapk14, Map2k1 |
PATH:04621 | NOD-like receptor signaling pathway | 3.4526 | 0.0195 | 5 | Mapk9, Mapk14 |
PATH:04620 | Toll-like receptor signaling pathway | 3.3364 | 0.0044 | 8 | Mapk9, Mapk14, Map2k1 |
PATH:04622 | RIG-I-like receptor signaling pathway | 3.0523 | 0.0301 | 5 | Mapk9, Mapk14 |
PATH:04066 | HIF-1 signaling pathway | 3.03588 | 0.0074 | 8 | Map2k1 |
PATH:04068 | FoxO signaling pathway | 2.8081 | 0.0075 | 9 | Mapk9, Foxo3, Mapk14, Map2k1 |
PATH:04141 | Protein processing in endoplasmic reticulum | 2.4924 | 0.0106 | 10 | Mapk9 |
PATH:04380 | Osteoclast differentiation | 2.3217 | 0.0396 | 7 | Mapk9, Mapk14, Map2k1 |
PATH:04010 | MAPK signaling pathway | 2.0206 | 0.0189 | 13 | Mapk9, Mapk14, Map2k1 |
PATH:04151 | PI3K-Akt signaling pathway | 1.8052 | 0.0291 | 15 | Foxo3, Map2k1 |
PATH:04066 | HIF-1 signaling pathway | -3.5287 | 0.0321 | 4 | Pik3r3 |
PATH:04070 | Phosphatidylinositol signaling system | -6.0445 | 0.0021 | 5 | Ocrl, Pik3r3, Synj2 |