Table 2 KEGG pathway analysis for differentially expressed genes between JS1 and JS2 cells and the key regulatory genes
Pathway ID | Pathway term | Enrichment (+, up; −, down) | P value | No. of DifGenes | Gene-act-network core genes (degree >5) | Co-expression network core genes (Dif-degree >5) |
|---|---|---|---|---|---|---|
path:mmu04115 | p53 signaling pathway | +1.971 | 0.013637 | 18 | Ccnd1, Igf1 | Apaf1 |
path:mmu0415 | mTOR signaling pathway | +1.934 | 0.030489 | 14 | Rps6ka1, Pik3r3, Mapk1, Igf1, Braf, Ins2 | Rps6ka1 |
path:mmu04621 | NOD-like receptor signaling pathway | +1.857 | 0.0298641 | 16 | Mapk1, Mapk12, Map3k7 | Tab3, Birc2 |
path:mmu04630 | Jak-STAT signaling pathway | +1.511 | 0.049774 | 25 | Jak2,Stat5b,Stat5a, Il6st, Pik3r3, Akt3,Ptpn11,Stat3,Ifnar1,Stat6, Stat2 | Jak2, Stat5a, Stat5b, Il6st, Grb2, Il20rb, Socs5 |
path:mmu04062 | Chemokine signaling pathway | +1.489 | 0.042555 | 29 | Jak2,Prkacb, Gsk3b, Mapk1, Kras, Plcb3, Gnai3, Cdc42, Braf,Stat5b, Stat3, Shc4, Pard3, Il11ra1 | Jak2, Prkacb , Gsk3b, Grb2 |
path:mmu04510 | Focal adhesion | +1.469 | 0.025892 | 39 | Pdgfra, Pdgfrb, Prkca, Gsk3b, Fn1, Mapk1, Itga11, Igf1r, Jun,Akt3, Igf1, Tnc, Braf, Col5a1, Col3a1, Col1a2, Col1a1, Thbs3, Thbs1, Col6a2, Col6a1, Col4a6, Tln2, Ugdh | Pdgfra, Pdgfrb, Prkca, Gsk3b, Fn1, Grb2, Birc2, Ppp1cb |
path:mmu05200 | Pathways in cancer | +1.350 | 0.032167 | 57 | Pdgfra, Pdgfrb, Prkca, Grb2, Gsk3b, Fn1, Pik3r3, Egfr, Mapk1, Kras, Jun, Akt3, Igf1, Braf, Stat5b, Stat5a, Figf, Cdk4, Stat3, Pias1, Mdm2 | Pdgfra, Pdgfrb, Prkca, Gsk3b, Fn1, Mmp2, Flt3l, Birc2, Brca2, Appl1, Casp3, Fzd1, Msh2 |
path:mmu04514 | Cell adhesion molecules (CAMs) | −1.493 | 0.046196 | 28 | H2-M2, LOC547349, H2-Q7, H2-Q2, Itgb7, Sdc3, LOC100044874, H2-M3, H2-T23, H2-T10, H2-K1, H2-Q8,H2-Q6, H2-Q10, Itgb6, H2-D1, Sdc2 | H2-M2, H2-Q7, Itgb7, LOC547349, H2-Q2, Sdc3, F11r, Madcam1, Selp |
path:mmu04145 | Phagosome | −1.640 | 0.006056 | 41 | H2-M2, H2-Q2, H2-Q7, LOC547349, LOC100044874, H2-M3, H2-T23, H2-T10, H2-K1, H2-Q8, H2-Q6, H2-Q10, H2-D1, Itgb5, Itgb3, Itga5, Actg1 | H2-M2, H2-Q2, H2-Q7, LOC547349, Atp6v0b, Atp6v1h, Atp6v1e1, Sec61b, Atp6v0c |
path:mmu04360 | Axon guidance | −1.653 | 0.013723 | 33 | Hras1, Mapk3, Ptk2, Nras, Tapbp | Hras1, Sema3a, Sema4f, Ephb3, Nfatc2 |
path:mmu04612 | Antigen processing and presentation | −1.886 | 0.012941 | 21 | H2-M2, H2-Q2, H2-Q7, LOC547349, LOC100044874, H2-M3, H2-T23, H2-T10, H2-K1, H2-Q6, H2-Q8, H2-Q10, H2-D1, Tapbp | H2-M2, H2-Q2, H2-Q7 , LOC547349 |