Fig. 1From: Dipeptidyl peptidase-4 and kidney fibrosis in diabetesMembrane-anchored DPP-4 and soluble DPP-4. Catalytically active DPP-4 is liberated from the plasma membrane to produce a soluble circulating form, sDPP-4, which lacks the intracellular tail and transmembrane regions and accounts for a substantial proportion of DPP-4 activity. In addition to its exopeptidase activity, DPP-4 also functions as a binding protein which can bind with fibronectin and adenosine deaminase (ADA)Back to article page