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Fig. 9 | Fibrogenesis & Tissue Repair

Fig. 9

From: Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1

Fig. 9

Enhanced Src and Lyn expression/activation in AA and SSc monocytes. a Extracts of monocytes from the indicated subjects (50 μg total protein per lane) from a representative experiment were analyzed by Western blot using the indicated primary antibodies. GAPDH was used as the loading control. b Densitometric quantification of pSrc and pLyn levels in monocytes from the indicated subjects. Values for individual subjects are shown (n = 7). c Western blot of a representative experiment using the indicated primary antibodies in which monocytes were treated with CSD (+) or control peptide (−). GAPDH was used as the loading control. d, e The average level of pSrc, Src, pLyn, and Lyn in C monocytes treated with control peptide was set to 100 arbitrary units. Note that both Src and Lyn are highly activated in SSc monocytes while only Src is activated in AA monocytes. Bars show the mean ± SEM from four independent experiments performed with cells from different subjects. ***p < 0.002; **p < 0.01; *p < 0.05

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