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Fig. 10 | Fibrogenesis & Tissue Repair

Fig. 10

From: Enhanced chemokine-receptor expression, function, and signaling in healthy African American and scleroderma-patient monocytes are regulated by caveolin-1

Fig. 10

MEK/ERK and Lyn/Src kinase inhibitors inhibit monocyte migration toward SDF-1, MCP-1, and MCP-3. Migration experiments were performed as described in the Methods using SSc (a) or C (b–d) monocytes. Chemokines used are indicated as are the treatment of monocytes with TGFβ, CSD, PP2, SU6656, and U0126. Data are expressed in terms of number of migrating cells counted per high power field. Bars show the mean level of migration ± SEM from four different subjects in each category determined in independent experiments. Note that while PP2, SU6656, and U0126 inhibit the migration of SSc monocytes and of C monocytes activated using TGFβ, they are not as effective as CSD. ***p < 0.002; **p < 0.01; *p < 0.05

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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