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Figure 3 | Fibrogenesis & Tissue Repair

Figure 3

From: Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

Figure 3

The overexpression of thrombospondin 1 (TSP1) in systemic sclerosis (SSc) fibroblasts is dependent on endogenous activation of ERK. Normal and SSc fibroblasts were treated with U0126 (ERK inhibitor) and interferon (IFN)b overnight, prior to determining protein expression by western blotting using an anti-TSP1 antibody (Abcam). U0126 and IFN inhibited the over expression of TSP1 protein in SSc fibroblasts.

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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