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Figure 2 | Fibrogenesis & Tissue Repair

Figure 2

From: Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

Figure 2

Thrombospondin 1 (TSP1) contributes to platelet-derived growth factor (PDGF) and transforming growth factor (TGF)b induced contractile activation in normal fibroblasts via the ERK signalling pathways. Normal fibroblasts were treated in collagen gels with or without PDGF(P), TGFb or INFb (IFN), and in the presence of PDGF and the PDGF receptor inhibitor Gleevac (Gle), or combined TGFb and INFb. Following gel contraction samples were analysed by western blotting for expression of total ERK and phospho-ERK compared to control untreated cells (C). PDGF and TGFb induced the levels of phospho-ERK, which were inhibited in the presence of Gleevac and IFNb respectively.

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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