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Figure 1 | Fibrogenesis & Tissue Repair

Figure 1

From: Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

Figure 1

Blocking thrombospondin-1 (TSP1) signalling with a LSKL peptide reduces ERK phosphorylation in control and systemic sclerosis (SSc) fibroblasts. Following gel contraction in the presence of TSP1 blocking peptide LSKL (AnaSpec), fibroblast lysates were prepared for western blotting and membranes probed with antibodies against total ERK and phospho-ERK (both from Cell Signalling) and GAPDH (Abcam) as the loading control. LSKL peptide reduced the expression of phospho-ERK in SSc fibroblasts.

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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