TY - JOUR AU - Sadasivan, Satish Kumar AU - Siddaraju, Nethra AU - Khan, Khaiser Mehdi AU - Vasamsetti, Balamuralikrishna AU - Kumar, Nimisha R. AU - Haridas, Vibha AU - Reddy, Madhusudhan B. AU - Baggavalli, Somesh AU - Oommen, Anup M. AU - Pralhada Rao, Raghavendra PY - 2015 DA - 2015/01/09 TI - Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices JO - Fibrogenesis & Tissue Repair SP - 1 VL - 8 IS - 1 AB - Precision-cut liver slices present different cell types of liver in a physiological context, and they have been explored as effective in vitro model systems to study liver fibrosis. Inducing fibrosis in the liver slices using toxicants like carbon tetrachloride is of less relevance to human disease conditions. Our aim for this study was to establish physiologically relevant conditions in vitro to induce fibrotic phenotypes in the liver slices. SN - 1755-1536 UR - https://doi.org/10.1186/s13069-014-0017-2 DO - 10.1186/s13069-014-0017-2 ID - Sadasivan2015 ER -