TY - JOUR AU - Li, Xiaojun AU - Zhuang, Shougang PY - 2014 DA - 2014/10/02 TI - Recent advances in renal interstitial fibrosis and tubular atrophy after kidney transplantation JO - Fibrogenesis & Tissue Repair SP - 15 VL - 7 IS - 1 AB - Although kidney transplantation has been an important means for the treatment of patients with end stage of renal disease, the long-term survival rate of the renal allograft remains a challenge. The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed “interstitial fibrosis and tubular atrophy” (IF/TA) to reflect the histologic pattern seen on biopsy. The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. In this review, we highlight the recent advances in our understanding of IF/TA from three aspects: pathogenesis, diagnosis, and treatment. SN - 1755-1536 UR - https://doi.org/10.1186/1755-1536-7-15 DO - 10.1186/1755-1536-7-15 ID - Li2014 ER -