Figure 6

Bleomycin-induced lung fibrosis in Sfrp1^−/−mice. (A) Ashcroft score 4 weeks after PBS or bleomycin instillation, from WT mice (PBS n = 5, BLM n = 6) and Sfrp1^−/− mice (PBS n = 5, BLM n = 11). (B) Hydroxyproline content of left lungs 4 weeks after PBS or bleomycin instillation from WT mice (PBS n = 4, BLM n = 5) and Sfrp1^−/− mice (PBS n = 5, BLM n = 10). (C) Pulmonary compliance 4 weeks after PBS or bleomycin instillation of WT mice (PBS n = 3, BLM n = 4) and Sfrp1^−/− mice (PBS n = 6, BLM n = 11). (D) End-expiratory volume (EEV) 4 weeks after PBS or bleomycin instillation, quantified by μCT imaging in WT mice (PBS n = 5, BLM n = 8) and Sfrp1^−/− mice (PBS n = 5, BLM n = 11).