| |
Heart rate (bpm)
|
Maximum pressure (mmHg)
|
End-diastolic pressure (mmHg)
|
Ejection fraction (%)
|
Cardiac output (μL/min)
|
LV dP/dt max (mmHg/s)
|
|---|
|
CHF + MOCE
|
243.7 ± 21.1
|
110.5 ± 12.1
|
9.4 ± 3.4a
|
42.1 ± 14.3
|
23,234 ± 12,996
|
5,573 ± 689a
|
|
CHF
|
235.8 ± 16.1
|
102.7 ± 12.3b
|
28.7 ± 6.2b
|
33.6 ± 8.1b
|
19,001 ± 6,082b
|
3,921 ± 816b
|
|
SHAM
|
261.1 ± 39.4
|
122.5 ± 13.8
|
7.2 ± 2.3
|
63.0 ± 10.2
|
40,162 ± 16,010
|
6,928 ± 1,090
|
- Hemodynamic parameters were measured in sham, CHF and CHF treated with Mocetinostat. Sham (n = 8), CHF (n = 10), CHF + MOCE (n = 8). Data are presented as mean ± SD.
- aCHF + MOCE vs CHF, P <0.01.
- bCHF vs. SHAM, P <0.01.
- CHF, congestive heart failure; LV dP/dtmax, peak rate of left ventricular pressure rise; MOCE, Mocetinostat.
