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Figure 3 | Fibrogenesis & Tissue Repair

Figure 3

From: HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Figure 3

Expression pattern of HDAC1 and HDAC2 in infarcted and non-infarcted LV. Cross-sections of hearts from sham and 6w CHF rats were labeled with HDAC1 (red) (A-F), HDAC2 (red) (G-L), and α-MHC (green) antibodies. DAPI (Blue) is used to stain nuclei. HDAC1 was mainly expressed in interstitial cells, while HDAC2 was mainly expressed in cardiomyocytes in sham LV. In CHF, both HDAC1 and HDAC2 staining increased in interstitial cells in remote LV and infarcted area (Scar). Scale bars: 250 μm. α-MHC, Myosin heavy chain; CHF, congestive heart failure; HDAC, Histone Deacetylase; LV, left ventricle.

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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