Skip to main content
Figure 2 | Fibrogenesis & Tissue Repair

Figure 2

From: HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Figure 2

HDAC1 and HDAC2 levels are elevated in non-infarcted myocardium in 6w CHF. Non-infarcted myocardium (remote LV), RV and left atrium (LA) from sham, 3w CHF, and 6w CHF were lysed and separated in 4% to 12% Bis-Tris SDS/PAGE gel and blotted with HDAC1 and HDAC2 antibodies. GADPH levels were used as loading control. Western blotting of the remote LV showed significant increases in HDAC1 and HDAC2 levels compared to sham in 6w CHF (A). Levels of HDAC1 were upregulated in 6w CHF RV (B). Both HDAC1 and HDAC2 levels were elevated in left atrium in 6w CHF (C). Error bars indicate S.E., P <0.05. CHF, congestive heart failure; HDAC, Histone Deacetylase; LV, left ventricle; RV, right ventricle. (n = 4 sham, n = 3 for 3w CHF) (n = 4 sham, n = 6 for 6w CHF).

Back to article page

Fibrogenesis & Tissue Repair

ISSN: 1755-1536

Contact us