Table 2 Tranilast administration causes a shift in fibre type proportions in the TA muscles of mdx mice

Tibialis anterior

 Fibre CSA (μm²)

1,811.4 ± 54.9

1,859.7 ± 74.3

1,890.2 ± 54.0

1,932.2 ± 113.6

 SDH intensity (o.d.)

1,645.4 ± 57.4

1,622.3 ± 36.6

1,497.2 ± 74.1^†

1,464.7 ± 48.9^†

 % Type IIa fibres

11.0 ± 3.1

9.1 ± 1.6

4.9 ± 0.6

10.8 ± 0.5*

Diaphragm

 Fibre CSA (μm²)

1,010.6 ± 69.3

949.8 ± 69.8

764.9 ± 39.9^†

874.6 ± 65.3^†

 SDH intensity (o.d.)

2,004.0 ± 63.9

1,725.6 ± 212.3

1,897.3 ± 46.2^†

1,793.1 ± 124.1^†

 % Type IIa fibres

63.8 ± 1.6

67.8 ± 3.9

71.5 ± 2.6^†

78.6 ± 3.3^†