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Table 2 Tranilast administration causes a shift in fibre type proportions in the TA muscles of mdx mice

From: Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice

  CON + VEH CON + TRA mdx + VEH mdx + TRA
Tibialis anterior
Fibre CSA (μm2) 1,811.4 ± 54.9 1,859.7 ± 74.3 1,890.2 ± 54.0 1,932.2 ± 113.6
SDH intensity (o.d.) 1,645.4 ± 57.4 1,622.3 ± 36.6 1,497.2 ± 74.1 1,464.7 ± 48.9
% Type IIa fibres 11.0 ± 3.1 9.1 ± 1.6 4.9 ± 0.6 10.8 ± 0.5*
Diaphragm
Fibre CSA (μm2) 1,010.6 ± 69.3 949.8 ± 69.8 764.9 ± 39.9 874.6 ± 65.3
SDH intensity (o.d.) 2,004.0 ± 63.9 1,725.6 ± 212.3 1,897.3 ± 46.2 1,793.1 ± 124.1
% Type IIa fibres 63.8 ± 1.6 67.8 ± 3.9 71.5 ± 2.6 78.6 ± 3.3
  1. At the conclusion of the treatment period the fibre cross-sectional area (CSA), fibre type and oxidative enzyme activity were determined by histological evaluations of cross-sections stained with H&E and reacted for succinate dehydrogenase (SDH) activity. P < 0.05, group main effect; *P < 0.05, tranilast-treated vs. vehicle-treated mdx mice.