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Table 1 Tranilast administration does not cause a long-term change in fibrotic gene expression in the diaphragm

From: Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice

 

CON + VEH

CON + TRA

mdx- VEH

mdx-TRA

Col1a1

1.00±0.09

0.83±0.13

3.42±0.42*

3.37±0.33*

Col2a1

1.00±0.28

1.23±0.47

0.79±0.20

0.92±0.34

Col3a1

1.00±0.10

0.89±0.13

3.72±0.26*

3.27±0.34*

Col4a1

1.00±0.06

0.87±0.11

1.31±0.14

1.35±0.13

Col5a1

1.00±0.09

0.91±0.08

3.46±0.24*

3.40±0.36*

COl6a1

1.00±0.06

0.87±0.11

1.31±0.14

1.35±0.13

Fn1

1.00±0.14

1.34±0.07

1.00±0.14

1.01±0.18

TGFβ1

1.00±0.11

0.86±0.07

1.48±0.04*

1.45±0.12*

  1. At the conclusion of the treatment period RNA was extracted and real-time PCR analysis was used to examine the expression level of genes known to be associated with fibrosis. *P < 0.05 mdx vs. control.
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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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