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Table 1 Tranilast administration does not cause a long-term change in fibrotic gene expression in the diaphragm

From: Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice

  CON + VEH CON + TRA mdx- VEH mdx-TRA
Col1a1 1.00±0.09 0.83±0.13 3.42±0.42* 3.37±0.33*
Col2a1 1.00±0.28 1.23±0.47 0.79±0.20 0.92±0.34
Col3a1 1.00±0.10 0.89±0.13 3.72±0.26* 3.27±0.34*
Col4a1 1.00±0.06 0.87±0.11 1.31±0.14 1.35±0.13
Col5a1 1.00±0.09 0.91±0.08 3.46±0.24* 3.40±0.36*
COl6a1 1.00±0.06 0.87±0.11 1.31±0.14 1.35±0.13
Fn1 1.00±0.14 1.34±0.07 1.00±0.14 1.01±0.18
TGFβ1 1.00±0.11 0.86±0.07 1.48±0.04* 1.45±0.12*
  1. At the conclusion of the treatment period RNA was extracted and real-time PCR analysis was used to examine the expression level of genes known to be associated with fibrosis. *P < 0.05 mdx vs. control.