Tranilast effects on fatigue of diaphragm muscle strips and tibialis anterior muscles of mdx mice. Analysis of the frequency-force relationship showed significant reductions in specific force in the mdx TA and diaphragm compared to controls, which was not altered with administration of tranilast (A/B). At the conclusion of treatment, resistance to fatigue was determined from intermittent stimulation of (C) diaphragm muscle strips evaluated in vitro or (D) TA muscles evaluated in situ, from vehicle or tranilast-treated mdx mice. Values are expressed as relative specific force (force per cross-sectional area) during the 4-min stimulation protocol. #P < 0.05 group main effect, mdx vs. control. *P < 0.05 treatment main effect.