Tranilast effects on muscle mass and whole body strength of mdx mice. Three-week-old male C57Bl/10 control mice or mdx mice received either vehicle or tranilast treatment for 9 weeks. (A) Individual muscle masses at the end of the treatment period. (B) Grip strength was measured 3 days prior to endpoint. (C) Whole body function and coordination was assessed by rotarod performance 2 days prior to endpoint. QUAD: quadriceps; GAST: gastrocnemius; TA: tibialis anterior; PLANT: plantaris; EDL: extensor digitorum longus; SOL: soleus. #P < 0.05 group main effect, mdx vs. control.