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Figure 6 | Fibrogenesis & Tissue Repair

Figure 6

From: Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases

Figure 6

BGM in CCL4 rats. (a) Mean circulating serum BGM levels in carbon tetrachloride (CCL4)-induced rat model of liver fibrosis measured at 8, 12, 16, and 20 weeks (CCL4-treated animals: n = 13; controls: n = 7 for each group). (b) Serum BGM levels in all control rats and all CCL4 rats stratified in quartiles according to total collagen content in the liver determined by Sirius red; (ns = non-significant, * P < 0.05, ** P < 0.01, *** P < 0.001). Correlation of circulating serum BGM and histological Sirius red quantification determining the extent of liver fibrosis in (c) CCL4-treated rats and (d) controls.

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