Cyclosporin A decreases Mmps mRNA expression in dermal fibroblasts. Quantitative RT-PCR determination of Mmps mRNA levels was analyzed in cultured CsA-treated dermal fibroblasts from nude and wild-type mice. Expression of Mmps mRNA was normalized to levels of Hprt1 mRNA. Triplicate assays were used and experiment was repeated three times each time using dermal fibroblasts isolated from different set of animals (n = 9). Error bars represent SEM; *p < 0.05; **p < 0.01; ***p < 0.001 (nude dermal fibroblasts) and #p < 0.05, ##p < 0.01 (wild type dermal fibroblasts) calculated relative to respective controls, untreated cells (0 ng/ml CsA).