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Figure 2 | Fibrogenesis & Tissue Repair

Figure 2

From: Function and fate of myofibroblasts after myocardial infarction

Figure 2

Summary of potential roles of microRNAs in regulating cardiac myofibroblast phenotype and function. microRNA (miR)-24, miR-30 and miR-133a inhibit transforming growth factor beta (TGF-β)-induced differentiation of resident cardiac myofibroblasts to myofibroblasts either directly or by reducing TGF-β levels. miR-21 and miR-125b stimulate conversion of endothelial cells to myofibroblasts via endothelial–mesenchymal transition (EndMT). Synthesis of extracellular matrix (ECM) proteins (for example, collagen) by myofibroblasts is upregulated by miR-21, miR-29 and miR-30, and miR-21 also stimulates cell migration and survival. In contrast, miR-29 inhibits cell survival. See main text for details.

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