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Table 1 Pathways represented within the microRNA targets common to the set of bleomycin-induced genes

From: MicroRNA profiling implicates the insulin-like growth factor pathway in bleomycin-induced pulmonary fibrosis in mice

Ingenuity canonical pathway

Minus log ( P-value)

Molecules

Axonal guidance signaling

4.5

EPHA7, ARHGEF12,SOS2,PTCH1,ITGA5,ROBO1,WNT2,EFNB2,FZD4,IGF1,EFNB1,GNA13,PRKD3,ADAM9,NRP1

Role of NANOG in mammalian embryonic stem cell pluripotency

3.65

SOX2,LIF,FZD4,GAB1,SOS2,BMPR2,WNT2

HGF signaling

3.07

ETS1,GAB1,SOS2,MAPK10,ETS2,PRKD3

Cholecystokinin/gastrin-mediated signaling

3.02

ITPR2,SOS2,MAPK10,RHOU,GNA13,PRKD3

Pantothenate and CoA biosynthesis

2.93

PANK1,ENPP1,ENPP5

Molecular mechanisms of cancer

2.82

ARHGEF12,FZD4,GAB1,SOS2,PTCH1,MAPK10,RHOU,BMPR2,HIF1A,GNA13,PRKD3

Endothelin-1 signaling

2.56

EDNRB,GAB1,ITPR2,MAPK10,MAPK6,GNA13,PRKD3

RAR activation

2.49

TAF4 RARB,IGFBP3,MAPK10,NCOR1,PRKD3,PPARGC1A

Mouse embryonic stem Cell pluripotency

2.37

SOX2,LIF,FZD4,SOS2,BMPR2

Phospholipase C signaling

2.35

ARHGEF12,ITPR2,SOS2,RHOU,RPS6KA3,ITGA5,GNA13,PRKD3

IGF-1 signaling

2.31

CTGF,IGF1,SOS2,IGFBP3,GRB10

Hepatic fibrosis/hepatic stellate cell activation

2.31

COL1A2,CTGF,IGF1,EDNRB,FLT1,IGFBP3

ERK5 signaling

2.29

LIF,GAB1,RPS6KA3,GNA13

Glioblastoma multiforme signaling

2.17

FZD4,IGF1,ITPR2,SOS2,RHOU,WNT2

Growth hormone signaling

2.15

IGF1,IGFBP3,RPS6KA3,PRKD3

GDNF family ligand-receptor interactions

2.15

GAB1,ITPR2,SOS2,MAPK10

Renal cell carcinoma signaling

2.11

ETS1,GAB1,SOS2,HIF1A