Figure 1

Bleomycin-induced pulmonary fibrosis phenotype of C57BL/6J mice. Mice were exposed to 100 U/kg of bleomycin through a mini-osmotic pump and euthanized six weeks later. Control mice were not treated. Images of left lung histological sections stained with Masson’s trichrome; magnification 100×. (A) C57BL/6J with regions of subpleural pulmonary fibrosis, as indicated by the blue collagen streaks. (B) C57BL/6J control. (C) Average fibrosis ± standard deviation of n = 3 mice per group.