Figure 10

Model of myofibroblast development. Resident fibroblasts are activated when the tissue is injured, and then begin to produce more collagen and chemokines. After activated fibroblasts differentiate into myofibroblasts, they still produce collagen, but they do not produce chemokines, as do fibroblasts and activated fibroblasts. Other types of cell, such as mesothelial cells, endothelial cells, epithelial cells, and circulating fibrocytes also participate in myofibroblast development.