Figure 1From: CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosisCTGF affects multiple signaling pathways and processes important in pathophysiology. CTGF interacts with a variety of molecules, including cytokines and growth factors, receptors and matrix proteins. These interactions alter signal transduction pathways, either positively or negatively, which results in changes in cellular responses.Back to article page