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Figure 3 | Fibrogenesis & Tissue Repair

Figure 3

From: Primary myelofibrosis and the "bad seeds in bad soil" concept

Figure 3

Role of growth factors in PMF stromal reaction. In PMF, myelofibrosis is a multifactor process resulting from alterations of fibroblasts/MSC leading to an increased deposit of extracellular matrix components resulting from growth factors released by malignant hematopoietic cells and especially MK and monocytes. These growth factors would further activate stromal cells, leading to myelofibrosis, osteosclerosis and neoangiogenesis.

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