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Table 2 Extrinsic mediators of fibroblast activity potentially implicated in SSc

From: Fibrosis in systemic sclerosis: common and unique pathobiology

Cytokines
TGF-β
IL-4
IL-13
IL-17
IL-33
Growth factors, peptides and bioactive lipids
Wnt family (Wnt3a, Wnt10b, others)
CTGF (matricellular protein)
PDGF
IGFBP-5
Endothelin-1
Adenosine
Lysophosphatidic acid (LPA)
Prostaglandin F
Chemokines
CXCL12
MCP-1
Autoantibodies
Antibody to Topo I
Anti-fibroblast antibody
Anti-PDGF antibody