Table 1 Intracellular signal mediators showing aberrant expression in SSc
From: Fibrosis in systemic sclerosis: common and unique pathobiology
Molecule | Increased expression/activity | Decreased expression/activity |
|---|---|---|
Egr-1, Egr-2 | ⇑ | |
Sp1 | ⇑ | |
p300/CBP | ⇑ | |
Fli-1 | ⇓ | |
Smad7 | ⇓ | |
Ski/Sno | ⇓ | |
Nab2 | ⇓ | |
PTEN | ⇓ | |
PPAR-gamma | ⇓ | |
microRNA29 | ⇓ |